Molecular structure of Compound W, CAS Number: 173550-33-9
Compound W (CAS 173550-33-9)
Alternate Names:
3,5-bis(4-Nitrophenoxy)benzoic acid
Application:
Compound W is a γ-secretase and &beta-amyloid inhibitor
CAS Number:
173550-33-9
Purity:
>99%
Molecular Weight:
396.3
Molecular Formula:
C19H12N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. The compound is a 3,3′-diiodothyronine sulfate cross-reactive substance, and is similar to N,N-dimethyl-T2S. Studies show that Compound W inhibits amyloid β peptides (Aβ) and has been used to test the analytical properties of the immunoprecipitation-liquid chromatography/mass spectrometry (ip-LC/MS) assay.
Compound W (CAS 173550-33-9) References
- Secretion of the Notch-1 Abeta-like peptide during Notch signaling. | Okochi, M., et al. 2006. J Biol Chem. 281: 7890-8. PMID: 16434391
- Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. | Wu, SY., et al. 2007. Pediatr Res. 61: 307-12. PMID: 17314688
- Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay. | Ford, MJ., et al. 2008. J Neurosci Methods. 168: 465-74. PMID: 18187205
- Thyroid function and 3,3'-diiodothyronine sulfate cross-reactive substance (compound W) in maternal hyperthyroidism with antithyroid treatment. | Vanmiddlesworth, L., et al. 2011. Endocr Pract. 17: 170-6. PMID: 20713348
- Modeling familial Alzheimer's disease with induced pluripotent stem cells. | Yagi, T., et al. 2011. Hum Mol Genet. 20: 4530-9. PMID: 21900357
- Synthesis and properties of polyurethane elastomers crosslinked with amine-terminated AB2-type hyperbranched polyamides. | Nasar, A. Sultan, et al. 2003. European polymer journal. 39.6: 1201-1208.
- P4–284: Effects of 3, 5–bis (4–nitrophenoxy)–benzoic acid on PS/γ–secretase cleavage. | Nakayama, Taisuke, et al. 2006. Alzheimer's & Dementia. 2: S600-S600.
- Novel Hyperbranched Poly (aryl ether urethane) s Using AB2‐Type Blocked Isocyanate Monomers and Copolymerization with AB‐Type Monomers. | Shanmugam, Thiyagarajan and A. Sultan Nasar. 2008. Macromolecular Chemistry and Physics. 209.6: 651-665.
- Solid‐phase synthesis of aromatic polyamide dendrons. | Tsushima, Hiroyuki, et al. 2011. Polymers for Advanced Technologies. 22.8: 1292-1296.
- Polyimide/nano-TiO2 hybrid films having benzoxazole pendent groups: in situ sol–gel preparation and evaluation of properties. | Toiserkani, Hojjat. 2015. Progress in Organic Coatings. 88: 17-22.
Inhibitor of:
beta-Amyloid, Enzyme, and Gamma-secretase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Compound W, 100 mg | sc-202553 | 100 mg | $138.00 |