Compound W CAS: 173550-33-9
MF: C19H12N2O8
MW: 396.3
A γ-secretase and &beta-amyloid inhibitor.

Compound W (CAS 173550-33-9)

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Synonym: 3,5-bis(4-Nitrophenoxy)benzoic acid
Application: A γ-secretase and &beta-amyloid inhibitor
CAS Number: 173550-33-9
Purity: >99%
Molecular Weight: 396.3
Molecular Formula: C19H12N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. The compound is a 3,3'-diiodothyronine sulfate cross-reactive substance, and is similar to N,N-dimethyl-T2S. Studies show that Compound W inhibits β-Amyloid (amyloid β peptides, Aβ) and has been used to test the analytical properties of the immunoprecipitation-liquid chromatography/mass spectrometry (ip-LC/MS) assay.


1. Okochi, M., et al. 2006. J. Biol. Chem. 281: 7890-7898. PMID: 16434391
2. Wu, S.Y., et al. 2007. Pediatr. Res. 61: 307-312. PMID: 17314688
3. Ford, M.J., et al. 2008. J. Neurosci. Methods. 168: 465-474. PMID: 18187205
4. Vanmiddlesworth, L., et al. 2010. Endocr Pract. [Epub ahead of print]. PMID: 20713348

Physical State :
Solubility :
Soluble in DMSO (100 mM), ethanol (5 mM), and 1.1eq. NaOH (50 mM).
Storage :
Store at 4° C
Melting Point :
246.56° C (Predicted)
Boiling Point :
577.66° C at 760 mmHg (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 3.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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After being dissolved in DMSO and stored at -20C, how long will this compound remain stable in solution?

Asked by: chemicalsmg
Thank you for your question. This chemical should be stable for up to 6 months after reconstitution. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-22
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