Molecular structure of Compound 48/80 trihydrochloride, CAS Number: 94724-12-6
Compound 48/80 trihydrochloride (CAS 94724-12-6)
Application:
Compound 48/80 trihydrochloride is a CaM (calmodulin) and PLC inhibitor
CAS Number:
94724-12-6
Purity:
≥98%
Molecular Weight:
630.11
Molecular Formula:
C32H46N3O3•3HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Compound 48/80 trihydrochloride is an oligomeric mixture of condensation products of formaldehyde and N-methyl-p-methoxyphenethylamine. The trimer is the most abundant oligomer of the mixture. This product may act to promote the release of histamine, inhibit CaM (calmodulin), inhibit PLC (phospholipase C) and activate G proteins by a mechanism analogous to that of mastoparan (sc-200831). Compound 48/80 trihydrochloride inhibits human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.
Compound 48/80 trihydrochloride (CAS 94724-12-6) References
- Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80. | Mousli, M., et al. 1990. FEBS Lett. 259: 260-2. PMID: 1688415
- Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. | Higashijima, T., et al. 1990. J Biol Chem. 265: 14176-86. PMID: 2117607
- Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. | Bronner, C., et al. 1987. Biochim Biophys Acta. 920: 301-5. PMID: 3607084
- Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. | Gietzen, K. 1983. Biochem J. 216: 611-6. PMID: 6141789
- Compound 48/80 is a selective and powerful inhibitor of calmodulin-regulated functions. | Gietzen, K., et al. 1983. Biochim Biophys Acta. 736: 109-18. PMID: 6317027
Inhibitor of:
CALML4, CaM, CaMKIδ, CaMKIIδ, CaMKIIγ, EDF1, GFAT2, hippocalcin, and PLC.Activator of:
Fc ε RIα, IL-3Rα, Mast Cell Protease 1, and Mast Cell Tryptase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Compound 48/80 trihydrochloride, 100 mg | sc-200736 | 100 mg | $104.00 | |||
Compound 48/80 trihydrochloride, 250 mg | sc-200736A | 250 mg | $218.00 | |||
Compound 48/80 trihydrochloride, 1 g | sc-200736B | 1 g | $843.00 | |||
Compound 48/80 trihydrochloride, 5 g | sc-200736C | 5 g | $3756.00 |