Compound 48/80 trihydrochloride CAS: 94724-12-6
MF: C32H46N3O3•3HCl
MW: 630.11
A CaM (calmodulin) and PLC inhibitor.

Compound 48/80 trihydrochloride (CAS 94724-12-6)

Compound 48/80 trihydrochloride | CAS 94724-12-6 is rated 5.0 out of 5 by 1.
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Application: A CaM (calmodulin) and PLC inhibitor
CAS Number: 94724-12-6
Molecular Weight: 630.11
Molecular Formula: C32H46N3O33HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Compound 48/80 trihydrochloride is an oligomeric mixture of condensation products of formaldehyde and N-methyl-p-methoxyphenethylamine. The trimer is the most abundant oligomer of the mixture. This product has been shown to promote the release of histamine, inhibit CaM (calmodulin), inhibit PLC (phospholipase C) and activate G proteins by a mechanism analogous to that of mastoparan (sc-200831). Compound 48/80 trihydrochloride inhibits human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.


References

1. Gietzen, K. 1983. Biochem. J. 216: 611-616. PMID: 6141789
2. Gietzen, K., et al. 1983. Biochim. Biophys. Acta. 736: 109-118. PMID: 6317027
3. Bronner, C., et al. 1987. Biochim. Biophys. Acta. 920: 301-305. PMID: 3607084
4. Mousli, M., et al. 1990. FEBS Lett. 259: 260-262. PMID: 1688415
5. Higashijima, T., et al. 1990. J. Biol. Chem. 265: 14176-14186. PMID: 2117607

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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Is sc-200736 PLC γ specific?

Asked by: Io5ay
Thank you for your question, At the moment, we do not have any references in literature to suggest that it is gamma specific. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-15
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Rated 5 out of 5 by from Mousii et al Mousii et al. (PubMed ID 1688415) found that Compound 48/80 trihydrochloride increased Mg2+-dependent activity of GTPase via G-protein activation. -SCBT Publication Review
Date published: 2015-03-29
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