Molecular structure of Compound 401, CAS Number: 168425-64-7
Compound 401 (CAS 168425-64-7)
See product citations (4)
Application:
Compound 401 is a selective inhibitor of DNA-PK and FRAP
CAS Number:
168425-64-7
Purity:
>95%
Molecular Weight:
281.3
Molecular Formula:
C16H15N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 µM). Compound 401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound 401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.
Compound 401 (CAS 168425-64-7) References
Ballou, L.M., et al. 2007. J. Biol. Chem. 282, 24463. Griffin, R.J., et al. 2005. J. Med. Chem. 48, 569Inhibitor of:
Aminopeptidase P2, DNA-PK, and mTOR.Activator of:
ATF-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Compound 401, 5 mg | sc-202552 | 5 mg | $75.00 |