Combretastatin A4 Phosphate Disodium Salt CAS: 168555-66-6
MF: C18H19Na2O8P
MW: 440.29
A microtubule depolymerizing molecule.

Combretastatin A4 Phosphate Disodium Salt (CAS 168555-66-6)

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Synonym: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(Dihydrogen phosphate) Sodium Salt CA 4P
Application: A microtubule depolymerizing molecule
CAS Number: 168555-66-6
Molecular Weight: 440.29
Molecular Formula: C18H19Na2O8P
* Refer to Certificate of Analysis for lot specific data (including water content).
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Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4 Phosphate Disodium Salt selectively inhibits endothelial tumor cells via disrupting VE-cadherin (vascular endothelial-cadherin). In addition, Combretastatin A4 Phosphate Disodium Salt can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. Furthermore, Combretastatin A4 Phosphate Disodium Salt can change the morphology of endothelial cells by altering their tubulin cytoskeleton.


References

1. West, C.M. and Price, P. 2004. Anticancer Drugs. 15: 179-187. PMID: 15014350
2. Young, S.L., et al. 2004. Expert Opin Investig Drugs. 13: 1171-1182. PMID: 15330748
3. Vincent, L., et al. 2005. J. Clin. Invest. 115: 2992-3006. PMID: 16224539
4. Nagaiah, G. and Remick, S.C. 2010. Future Oncol. 6: 1219-1228. PMID: 20799867

Physical State :
Solid
Solubility :
Soluble in Methanol
Storage :
Store at 4° C
Melting Point :
≥ 260° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918309
SMILES :
COC1=C(C=C(C=C1)/C=C\\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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