Collectin 43 Antibody (4F11): sc-80627

Collectin 43 Antibody (4F11) is a mouse monoclonal IgG1 antibody that detects Collectin 43 in bovine samples through western blotting (WB). Collectin 43 is a crucial component of the innate immune system in cows, functioning as a C-type serum lectin that plays a significant role in the defense against various pathogens, including viruses, fungi, and bacteria. Collectin 43 is synthesized in the liver and is composed of three identical chains, each featuring a collagen region and a C-type carbohydrate recognition domain, which allows binding to microbial surface carbohydrates in a calcium-dependent manner. Anti-Collectin 43 antibody (4F11) helps researchers understand how this protein induces aggregation of pathogens, impeding their infectivity and facilitating phagocytosis by immune cells, highlighting its importance in maintaining bovine health. The presence of two isoforms—native and truncated—of Collectin 43 suggests a complexity in function and variability in serum levels, which may be linked to disease states in cows. Collectin 43 (4F11) antibody serves as an essential tool for researchers studying immune response in bovine species, providing insights into pathogen recognition and clearance mechanisms.