Collectin 43 Antibody (260-01): sc-59148

Collectin 43 Antibody (260-01) is a mouse monoclonal IgG1 antibody that detects Collectin 43 in bovine samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Collectin 43 is a crucial component of the innate immune system in cows, functioning as a C-type serum lectin that plays a significant role in the defense against various pathogens, including viruses, fungi, and bacteria. This protein is synthesized in the liver and is composed of three identical chains, each featuring a collagen region and a C-type carbohydrate recognition domain, which allows binding to microbial surface carbohydrates in a calcium-dependent manner. Collectin 43′s ability to induce aggregation of pathogens not only impedes infectivity but also facilitates phagocytosis by immune cells, highlighting importance in maintaining bovine health. Additionally, the presence of two isoforms—native and truncated—of Collectin 43 may influence variability in serum levels, which has been associated with various diseases in cows, making Collectin 43 a valuable marker for understanding immune responses and disease states in veterinary medicine. Anti-Collectin 43 antibody (260-01) is an essential tool for researchers studying bovine immunology and pathogen defense mechanisms.