Date published: 2025-11-1

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Collagenase Inhibitor I (CAS 123984-15-6)

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Alternate Names:
Z-Pro-D-Leu-D-Ala-NHOH; Z-PDLDA-NHOH
Application:
Collagenase Inhibitor I is an MMP inhibitor
CAS Number:
123984-15-6
Molecular Weight:
448.52
Molecular Formula:
C22H32N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Collagenase Inhibitor I is a specific inhibitor of collagenase, an enzyme that breaks down collagen in the extracellular matrix. It works by binding to the active site of collagenase, it from degrading collagen. This inhibition of collagenase activity is important in maintaining the structural integrity of connective tissues. Collagenase Inhibitor I is to study the role of collagenase in various biological processes, including wound healing, tissue remodeling, and cancer metastasis. Its ability to target collagenase makes it a in understanding the complex interactions between cells and the extracellular matrix.


Collagenase Inhibitor I (CAS 123984-15-6) References

  1. Matrix metalloproteinase activities of turkey (Meleagris gallopavo) bile.  |  Rath, NC., et al. 2001. Comp Biochem Physiol C Toxicol Pharmacol. 130: 97-105. PMID: 11544146
  2. Macrophage interactions with neutrophils regulate Leishmania major infection.  |  Ribeiro-Gomes, FL., et al. 2004. J Immunol. 172: 4454-62. PMID: 15034061
  3. Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase.  |  Ribeiro-Gomes, FL., et al. 2007. J Immunol. 179: 3988-94. PMID: 17785837
  4. Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity.  |  Thornton, P., et al. 2008. Mol Cell Neurosci. 37: 135-42. PMID: 17939964
  5. The amount and activity of active matrix metalloproteinase 13 is suppressed by estradiol and progesterone in human pelvic floor fibroblasts.  |  Zong, W., et al. 2009. Biol Reprod. 80: 367-74. PMID: 18987329
  6. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.  |  Filardy, AA., et al. 2010. J Immunol. 185: 2044-50. PMID: 20660352
  7. Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids.  |  Odake, S., et al. 1990. Chem Pharm Bull (Tokyo). 38: 1007-11. PMID: 2165873
  8. Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns.  |  Leight, JL., et al. 2012. Cell Mol Bioeng. 5: 299-306. PMID: 23730348
  9. Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species.  |  Kassegne, K., et al. 2014. J Infect Dis. 209: 1105-15. PMID: 24277745
  10. A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (Barnett´s pitviper) snake venom with anti-platelet properties.  |  Sanchez, EF., et al. 2016. Biochim Biophys Acta. 1860: 542-56. PMID: 26723171
  11. Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy.  |  Miloudi, K., et al. 2016. J Clin Invest. 126: 3006-22. PMID: 27400127
  12. Chikungunya virus dissemination from the midgut of Aedes aegypti is associated with temporal basal lamina degradation during bloodmeal digestion.  |  Dong, S., et al. 2017. PLoS Negl Trop Dis. 11: e0005976. PMID: 28961239
  13. Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices.  |  Foidl, BM., et al. 2018. J Neurosci Methods. 295: 77-86. PMID: 29221639
  14. Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function.  |  Oliveira, LS., et al. 2019. Molecules. 24: PMID: 31561469

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Collagenase Inhibitor I, 5 mg

sc-221432
5 mg
$142.00