Date published: 2026-5-2
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Colivelin (CAS 867021-83-8) - chemical structure image
Molecular structure of Colivelin, CAS Number: 867021-83-8
Colivelin (CAS 867021-83-8) - chemical structure image
Molecular structure of Colivelin, CAS Number: 867021-83-8
Molecular structure of Colivelin, CAS Number: 867021-83-8

Colivelin (CAS 867021-83-8)

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Alternate Names:
Colivelin is also known as H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH.
Application:
Colivelin is a potent, synthetic, neuroprotective peptide and activator of STAT3, increasing STAT3 phosphorylation in vitro and in vivo.
CAS Number:
867021-83-8
Molecular Weight:
2645.13
Molecular Formula:
C119H206N32O35
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Colivelin suppresses neuronal death by activating STAT3 in vitro. Colivelin protects against β-amyloid neurotoxicity. Colivelin also upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer′s disease (AD) models. Colivelin prevents alcohol-induced apoptosis in a fetal mouse model. Colivelin is considered a brain penetrant. Colivelin is also known as H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH, and L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-proline.


Colivelin (CAS 867021-83-8) References

  1. Colivelin prolongs survival of an ALS model mouse.  |  Chiba, T., et al. 2006. Biochem Biophys Res Commun. 343: 793-8. PMID: 16564029
  2. Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin.  |  Chiba, T., et al. 2007. Mol Neurobiol. 35: 55-84. PMID: 17519506
  3. A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.  |  Sari, Y., et al. 2009. Neuroscience. 164: 1653-64. PMID: 19782727
  4. Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats.  |  Wu, MN., et al. 2015. Hippocampus. 25: 363-72. PMID: 25332198
  5. New labeled derivatives of the neuroprotective peptide colivelin: synthesis, characterization, and first in vitro and in vivo applications.  |  Kostomoiri, M., et al. 2015. Arch Biochem Biophys. 567: 83-93. PMID: 25575783
  6. Protective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model.  |  Yin, R., et al. 2016. Cell Physiol Biochem. 38: 1138-46. PMID: 26964005
  7. Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice.  |  Wu, M., et al. 2017. J Alzheimers Dis. 59: 1067-1078. PMID: 28731445
  8. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.  |  Zhao, H., et al. 2019. Neuroscience. 416: 198-206. PMID: 31374230
  9. AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.  |  Wang, X., et al. 2021. Mol Med Rep. 24: PMID: 34590152
  10. PIAS3/SOCS1-STAT3 axis responses to oxidative stress in hepatocellular cancer cells.  |  Sun, H., et al. 2021. Am J Transl Res. 13: 12395-12409. PMID: 34956461
  11. SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells.  |  Zhang, Y., et al. 2022. Gene. 821: 146190. PMID: 35124149
  12. GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma.  |  Gao, H., et al. 2022. Cancer Biol Ther. 23: 369-377. PMID: 35491899
  13. Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.  |  Urban, C., et al. 2022. Front Immunol. 13: 984298. PMID: 36119052

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Colivelin, 1 mg

sc-361153
1 mg
$612.00

Is Colivelin specific for the activation of STAT3, and what else transcription factors are activated by Colivelin?

Asked by: boc_111
It is a STAT3 activator; also protects against β-amyloid neurotoxicity, but we do not know more about this. Here is some literature that may be helpful: Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vit J.Neurosci. 25 10252 PMID: 16267233 Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653 PMID: 19782727 Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020 PMID: 17928813
Answered by: Technical Support
Date published: 2023-07-30

Is this soluble in DMSO?

Asked by: chemsd02
Thank you for your question. sc-361153 (Colivelin, CAS# 867021-83-8) is hydrophobic. DMSO is a good choice for a solvent. Our recommended concentration is 1 mg/mL.
Answered by: Chemical Support 10
Date published: 2023-07-30
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Rated 5 out of 5 by from 质量不错 发货速度快一周前买了此产品 性能指标满足实验要求，已经推荐给实验室其他人，希望产品以后能赠送个小样，很高兴那么快能收到货
Date published: 2022-12-13
Rated 5 out of 5 by from Induce RANKL expression in murine osteoblastsThis product (0.1 or 1.0 μM) induce RANKL expression in primary calvarial cells in mice. PLoS ONE 12(7):e0181126 · July 2017
Date published: 2017-08-04
Rated 5 out of 5 by from Wu et alWu et al. (PubMed ID 25332198) showed that colivelin (CLN) exhibited neurotprotective properties against the neurotoxic effects of Alzheimer s disease by inhibiting hippocampal A 25-35 in rats. -SCBT Publication Review
Date published: 2015-02-24
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Colivelin is rated 5.0 out of 5 by 3.
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