Molecular structure of Colchicine-d6, CAS Number: 1217651-73-4
Colchicine-d6 (CAS 1217651-73-4)
Application:
Colchicine-d6 is an isotopically labeled antimitotic agent
CAS Number:
1217651-73-4
Molecular Weight:
405.47
Molecular Formula:
C22H19D6NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An isotopically labeled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Induces apoptosis in several normal and tumor cell lines. Stimulates the intrinsic GTPase activity of tubulin.
Colchicine-d6 (CAS 1217651-73-4) References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Simultaneous determination of colchicine and febuxostat in rat plasma: Application in a rat pharmacokinetic study. | Gabani, BB., et al. 2020. Biomed Chromatogr. 34: e4939. PMID: 32614997
- Development, validation, and clinical application of a rapid UPLC-MS/MS method for detection of colchicine in human whole blood and urine. | Bi, C., et al. 2022. Biomed Chromatogr. 36: e5437. PMID: 35766796
- A Phase I Study to Evaluate the Pharmacokinetic Drug‒Drug Interaction of HP501, Febuxostat, and Colchicine in Male Chinese Patients with Hyperuricemia. | Ding, R., et al. 2023. Clin Drug Investig. 43: 401-411. PMID: 37248357
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Colchicine-d6, 1 mg | sc-217948 | 1 mg | $400.00 |