Molecular structure of Colchicine-d3
Colchicine-d3
Alternate Names:
Colsaloid-d3
Application:
Colchicine-d3 is an isotopically labeled antimitotic agent
Molecular Weight:
402.46
Molecular Formula:
C22H22D3NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
An isotopically labeled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Induces apoptosis in several normal and tumor cell lines. Stimulates the intrinsic GTPase activity of tubulin.
Colchicine-d3 References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Are dosing adjustments required for colchicine in the elderly compared with younger patients? | Wason, S., et al. 2012. Adv Ther. 29: 551-61. PMID: 22753019
- Effect of cyclosporine on the pharmacokinetics of colchicine in healthy subjects. | Wason, S., et al. 2012. Postgrad Med. 124: 189-96. PMID: 22913907
- Effects of grapefruit and Seville orange juices on the pharmacokinetic properties of colchicine in healthy subjects. | Wason, S., et al. 2012. Clin Ther. 34: 2161-73. PMID: 22940371
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Colchicine-d3, 1 mg | sc-217947 | 1 mg | $360.00 |