Molecular structure of Colchiceine, CAS Number: 477-27-0
Colchiceine (CAS 477-27-0)
Application:
Colchiceine is a metabolite of Colchicine
CAS Number:
477-27-0
Purity:
≥97%
Molecular Weight:
385.41
Molecular Formula:
C21H23NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Colchiceine is a toxic compound that has a similar structure to colchicine, a well-known alkaloid with anti-inflammatory and anti-gout properties. Colchiceine is a derivative of colchicine and is formed by the demethylation of the latter. In biochemistry, colchiceine is of interest due to its potential as a precursor for the synthesis of colchicine and other related compounds. Its structure and reactivity make it a useful starting material for the development of chemicals for studying microtubule dynamics and cell division. Colchiceine exhibits cytotoxic effects, making it a useful compound for investigating the mechanisms of cell death and apoptosis. Colchiceine is a promising molecule in the field of biochemistry and chemical biology.
Colchiceine (CAS 477-27-0) References
- Tautomeric selectivity towards colchicinoids in the tosylation of colchiceine on a heterogeneous, easily removable catalyst. | Cavazza, M. and Pietra, F. 2003. Org Biomol Chem. 1: 3002-3. PMID: 14518119
- Behavior of drug excited states within macromolecules: binding of colchicine and derivatives to albumin. | Bosca, F. and Tormos, R. 2013. J Phys Chem B. 117: 7528-34. PMID: 23730875
- Distribution of corticotropin-releasing factor in the tree shrew brain. | Shu, YM., et al. 2015. Brain Res. 1618: 270-85. PMID: 26074350
- Facial lesions heralding the onset and relapse of eosinophilic fasciitis. | Bachmeyer, C., et al. 2016. Clin Exp Dermatol. 41: 456-7. PMID: 26344940
- Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone. | Yagnik, D. and Hills, F. 2018. Mol Med Rep. 18: 3506-3512. PMID: 30066887
- Antifungal, anticancer, and docking studies of colchiceine complexes with monovalent metal cation salts. | Kurek, J., et al. 2019. Chem Biol Drug Des. 94: 1930-1943. PMID: 31260187
- Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii. | Rocchetti, G., et al. 2019. Antioxidants (Basel). 8: PMID: 31835669
- Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine. | Czerwonka, D., et al. 2020. Molecules. 25: PMID: 32151042
- Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives. | Czerwonka, D., et al. 2021. J Org Chem. 86: 11029-11039. PMID: 33350834
- Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs. | Pyta, K., et al. 2022. J Enzyme Inhib Med Chem. 37: 597-605. PMID: 35067138
- Interaction of Colchicine-Site Ligands With the Blood Cell-Specific Isotype of β-Tubulin-Notable Affinity for Benzimidazoles. | Montecinos, F., et al. 2022. Front Cell Dev Biol. 10: 884287. PMID: 35712668
- IMPPAT 2.0: An Enhanced and Expanded Phytochemical Atlas of Indian Medicinal Plants. | Vivek-Ananth, RP., et al. 2023. ACS Omega. 8: 8827-8845. PMID: 36910986
- Aryl glyoxal: a prime synthetic equivalent for multicomponent reactions in the designing of oxygen heterocycles. | Sheikh, AR., et al. 2023. RSC Adv. 13: 11652-11684. PMID: 37063730
Inhibitor of:
β2B Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Colchiceine, 10 mg | sc-207452 | 10 mg | $359.00 |