coilin Antibody (56): sc-135871
- coilin Antibody (56) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/500 µl
- raised against amino acids 226-332 of coilin of human origin
- recommended for detection of coilin of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for coilin Antibody (56). This work is in progress.
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Coilin Antibody (56) is a mouse monoclonal IgG1 antibody that detects coilin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-coilin antibody (56) plays a crucial role in the study of nuclear coiled bodies, which are small nuclear organelles essential for RNA transcription and processing. Coilin (56) antibody enables research on coilin′s vital role in the proper formation of Cajal bodies, as coilin contains a nucleolar localization signal and is a self-associating protein. Notably, coilin is involved in the recruitment of small nuclear ribonucleoproteins (snRNPs) and survival motor neuron (SMN) complex proteins to Cajal bodies, directly binding to SMN proteins and competing with SmB′ for these interactions. This recruitment is particularly important during the development of the organism, as Cajal bodies contribute to the assembly of the nucleolus. The structural dynamics of coilin are also significant; the N-terminus contains the self-associating domain, while the C-terminus regulates the number of Cajal bodies present in the cell, highlighting coilin′s importance in maintaining cellular function and organization.
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coilin Antibody (56) References:
- The C-terminal domain of coilin interacts with Sm proteins and U snRNPs. | Xu, H., et al. 2005. Chromosoma. 114: 155-66. PMID: 16003501
- Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. | Hearst, SM., et al. 2009. J Cell Sci. 122: 1872-81. PMID: 19435804
- Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. | Walker, MP., et al. 2009. PLoS One. 4: e6171. PMID: 19587784
- Human UBL5 protein interacts with coilin and meets the Cajal bodies. | Svéda, M., et al. 2013. Biochem Biophys Res Commun. 436: 240-5. PMID: 23726919
- Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis. | Enwerem, II., et al. 2014. Biol Open. 3: 240-9. PMID: 24659245
- Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance. | Chen, Y., et al. 2015. Nucleic Acids Res. 43: 385-95. PMID: 25477378
- Increased chemo-sensitivity by knockdown coilin expression involved acceleration of premature cellular senescence in HeLa cells. | Song, Y., et al. 2017. Biochem Biophys Res Commun. 489: 123-129. PMID: 28536075
- The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization. | Yao, Y., et al. 2020. Genes (Basel). 11: PMID: 32764415
- UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells. | Niu, H., et al. 2022. Cell Commun Signal. 20: 18. PMID: 35151311
- Analysis of the Arabidopsis coilin mutant reveals a positive role of AtCOILIN in plant immunity. | Abulfaraj, AA., et al. 2022. Plant Physiol. 190: 745-761. PMID: 35674377
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
coilin Antibody (56) | sc-135871 | 50 µg/500 µl | $322.00 |