COG6 Antibody (RR2): sc-101276

COG6 Antibody (RR2) is a mouse monoclonal IgG1 kappa light chain antibody that detects the COG6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-COG6 antibody (RR2) is available as a non-conjugated format. COG6, also known as COD2, is a crucial component of the conserved oligomeric Golgi (COG) complex, which plays a vital role in maintaining the structure and function of the Golgi apparatus. This complex is essential for various cellular processes, including glycosylation and vesicular transport, and consists of three subcomplexes: LDLC, SEC34, and GTC (Golgi transport complex). COG6 is a peripheral membrane protein composed of 657 amino acids and is predominantly expressed in the brain and ovary. COG6 functions to maintain Golgi structure and facilitate vesicle docking and fusion, which are necessary for effective intracellular transport. Notably, COG6 undergoes alternative splicing, resulting in three distinct isoforms, each potentially contributing to the complex′s diverse functions. COG6′s interaction with other proteins within the COG complex underscores its importance in cellular homeostasis and highlights its potential as a target for further research in understanding Golgi-related disorders.

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COG6 Antibody (RR2) References:

1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.  |  Hirosawa, M., et al. 1999. DNA Res. 6: 329-36. PMID: 10574461
2. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.  |  Whyte, JR. and Munro, S. 2001. Dev Cell. 1: 527-37. PMID: 11703943
3. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.  |  Loh, E. and Hong, W. 2002. J Biol Chem. 277: 21955-61. PMID: 11929878
4. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.  |  Ungar, D., et al. 2002. J Cell Biol. 157: 405-15. PMID: 11980916
5. The binary interacting network of the conserved oligomeric Golgi tethering complex.  |  Loh, E. and Hong, W. 2004. J Biol Chem. 279: 24640-8. PMID: 15047703
6. COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.  |  Kudlyk, T., et al. 2013. Traffic. 14: 194-204. PMID: 23057818
7. Key features and clinical variability of COG6-CDG.  |  Rymen, D., et al. 2015. Mol Genet Metab. 116: 163-70. PMID: 26260076
8. COG6-CDG: Expanding the phenotype with emphasis on glycosylation defects involved in the causation of male disorders of sex development.  |  Mandel, H., et al. 2020. Clin Genet. 98: 402-407. PMID: 32683677
9. Neonatal presentation of COG6-CDG with prominent skin phenotype.  |  Komlosi, K., et al. 2020. JIMD Rep. 55: 51-58. PMID: 32905044
10. COG6-CDG: Novel variants and novel malformation.  |  Cirnigliaro, L., et al. 2022. Birth Defects Res. 114: 165-174. PMID: 35068072
11. Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.  |  Ulrich, A., et al. 2024. Nat Commun. 15: 330. PMID: 38184627
12. Clinical and molecular characteristics of 26 fetuses with lethal multiple congenital contractures.  |  Turgut, GT., et al. 2024. Clin Genet. 105: 596-610. PMID: 38278647

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COG6 Antibody (RR2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COG6 Antibody (RR2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COG6 Antibody (RR2) Specifications

Alternate Product Name: COG6

Product Clone Name: RR2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 558-658

Epitope Target: COG6

Epitope Species: human

Product Reactivity/Detection: COG6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COG6 Antibody (RR2): N/A