COG2 Antibody (GA99): sc-130444

COG2 Antibody (GA99) is a mouse monoclonal IgG2b kappa light chain antibody that detects COG2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-COG2 antibody (GA99) is available as the non-conjugated format. COG2, also known as conserved oligomeric Golgi complex subunit 2 or LDLC, is a crucial 730 amino acid component of the conserved oligomeric Golgi (COG) complex, which is essential for maintaining the structure and function of the Golgi apparatus. This complex is composed of three subcomplexes—LDLC, SEC34, and GTT—that work together to facilitate glycosylation reactions and vesicular transport. COG2 is specifically localized to the cytoplasmic side of the Golgi apparatus, where COG2 plays a vital role in Golgi ribbon formation and the proper functioning of vesicular transport mechanisms. The importance of COG2 extends beyond structural integrity; COG2 dysfunction can lead to significant cellular consequences, including cell death, highlighting COG2′s critical role in cell viability and overall cellular health. COG2 (GA99) monoclonal antibody enables valuable insights into the mechanisms governing Golgi apparatus function and the implications of COG2 in various cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

COG2 Antibody (GA99) References:

1. High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking.  |  Kim, DW., et al. 1999. Mol Biol Cell. 10: 3317-29. PMID: 10512869
2. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.  |  Whyte, JR. and Munro, S. 2001. Dev Cell. 1: 527-37. PMID: 11703943
3. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.  |  Ungar, D., et al. 2002. J Cell Biol. 157: 405-15. PMID: 11980916
4. The binary interacting network of the conserved oligomeric Golgi tethering complex.  |  Loh, E. and Hong, W. 2004. J Biol Chem. 279: 24640-8. PMID: 15047703
5. Retrograde transport on the COG railway.  |  Ungar, D., et al. 2006. Trends Cell Biol. 16: 113-20. PMID: 16406524
6. The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.  |  Sohda, M., et al. 2007. Traffic. 8: 270-84. PMID: 17274799
7. Structural analysis of conserved oligomeric Golgi complex subunit 2.  |  Cavanaugh, LF., et al. 2007. J Biol Chem. 282: 23418-26. PMID: 17565980
8. LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function.  |  Podos, SD., et al. 1994. J Cell Biol. 127: 679-91. PMID: 7962052