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Coenzyme Q10 (CAS 303-98-0)

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Alternate Names:
CoQ10; Ubidecarenone; Ubiquinone-10; Q-10
Application:
Coenzyme Q10 is a mitochondrial transporter chain component
CAS Number:
303-98-0
Purity:
≥98%
Molecular Weight:
863.37
Molecular Formula:
C59H90O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes.


Coenzyme Q10 (CAS 303-98-0) References

  1. Calcium binding and transport by coenzyme Q.  |  Bogeski, I., et al. 2011. J Am Chem Soc. 133: 9293-303. PMID: 21548646
  2. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways.  |  Tsai, KL., et al. 2012. J Nutr Biochem. 23: 458-68. PMID: 21684136
  3. Enhanced water dispersibility of coenzyme Q10 by complexation with albumin hydrolysate.  |  Matsushita, N., et al. 2013. J Agric Food Chem. 61: 5972-8. PMID: 23731056
  4. Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders.  |  Stepien, KM., et al. 2017. J Clin Med. 6: PMID: 28753922
  5. Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases.  |  Zhang, X., et al. 2017. Curr Med Chem. 24: 4329-4339. PMID: 28762311
  6. The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression.  |  Wigner, P., et al. 2018. Psychiatry Res. 262: 566-574. PMID: 28951145
  7. Ovarian Stimulation in Poor Responders: Have We Made Progress?  |  Roman, R., et al. 2017. Curr Pharm Biotechnol. 18: 614-618. PMID: 28969562
  8. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.  |  Stockwell, BR., et al. 2017. Cell. 171: 273-285. PMID: 28985560
  9. Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms? Pharmacological and Methodological Considerations.  |  Taylor, BA. 2018. Am J Cardiovasc Drugs. 18: 75-82. PMID: 29027135
  10. The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10.  |  Guescini, M., et al. 2017. Oxid Med Cell Longev. 2017: 7083049. PMID: 29123615
  11. Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases.  |  Morris, G., et al. 2018. Behav Brain Res. 341: 154-175. PMID: 29289598
  12. Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.  |  Montenegro, L., et al. 2018. Nanomaterials (Basel). 8: PMID: 29401722
  13. Neurotrophic keratopathy.  |  Dua, HS., et al. 2018. Prog Retin Eye Res. 66: 107-131. PMID: 29698813
  14. CoQ10 a super-vitamin: review on application and biosynthesis.  |  Shukla, S. and Dubey, KK. 2018. 3 Biotech. 8: 249. PMID: 29755918

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Coenzyme Q10, 1 g

sc-205262
1 g
$70.00

Coenzyme Q10, 5 g

sc-205262A
5 g
$180.00

hello, is this synthetic or extracted from animal sources?

Asked by: umme
Thank you for your question. This product is synthesised through fermentation.
Answered by: Tech Support Europe
Date published: 2022-10-06

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Coenzyme Q10, sc-205262, is a yellow to orange crystalline powder
Answered by: TechService7
Date published: 2017-01-16
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Rated 5 out of 5 by from BelousovaBelousova, MA. et al. (PubMed 26371950) reported that intravenous treatment with Coenzyme Q10 improves neurological outcome and reduces infarct volume after transient focal brain ischemia in rats. -SCBT Publication Review
Date published: 2015-05-01
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Coenzyme Q10 is rated 5.0 out of 5 by 1.
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