Codanin-1 Antibody (G-1): sc-365839
- Codanin-1 Antibody (G-1) is a mouse monoclonal IgG1 κ Codanin-1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 780-1080 mapping near the C-terminus of Codanin-1 of human origin
- Codanin-1 Antibody (G-1) is recommended for detection of Codanin-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Codanin-1 Antibody (G-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Codanin-1 Antibody (G-1) for WB applications. These reagents are now offered in bundles with Codanin-1 Antibody (G-1) (see ordering information below).
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Codanin-1 Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Codanin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Codanin-1 antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Codanin-1, encoded by the CDAN1 gene located on chromosome 15q15.2, consists of 1,227 amino acids and features a 150-residue N-terminal domain that shares sequence similarity with collagens, as well as two shorter segments that exhibit weak homology to microtubule-associated proteins such as synapsin and MAP-1B. This structural composition suggests a potential role for Codanin-1 in maintaining nuclear envelope integrity, which is crucial for proper cellular function and organization. Mutations in the CDAN1 gene are linked to congenital dyserythropoietic anemia type 1 (CDA1), a rare autosomal recessive disorder characterized by ineffective erythropoiesis and morphological abnormalities in erythroblasts, highlighting the importance of Codanin-1 in hematopoiesis and overall skeletal development. Codanin-1 (G-1) antibody in various formats serves as an essential tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Codanin-1 Antibody (G-1) References:
- Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. | Dgany, O., et al. 2002. Am J Hum Genet. 71: 1467-74. PMID: 12434312
- Red cell membrane and erythropoiesis genetic defects. | Delaunay, J. 2003. Hematol J. 4: 225-32. PMID: 12872147
- The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj. | Pielage, J., et al. 2003. Dev Cell. 5: 841-51. PMID: 14667407
- Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation. | Heimpel, H., et al. 2006. Blood. 107: 334-40. PMID: 16141353
- Evidence of genetic heterogeneity in congenital dyserythropoietic anaemia type I. | Ahmed, MR., et al. 2006. Br J Haematol. 133: 444-5; author reply 446. PMID: 16643456
- Linkage and mutational analysis of the CDAN1 gene reveals genetic heterogeneity in congenital dyserythropoietic anemia type I. | Ahmed, MR., et al. 2006. Blood. 107: 4968-9. PMID: 16754775
- Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. | Goede, JS., et al. 2006. Ann Hematol. 85: 591-5. PMID: 16767397
- Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. | Tamary, H., et al. 1996. Blood. 87: 1763-70. PMID: 8634422
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Codanin-1 Antibody (G-1) | sc-365839 | 200 µg/ml | $322.00 | |||
Codanin-1 Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-529487 | 200 µg Ab; 10 µg BP | $361.00 | |||
Codanin-1 Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-522389 | 200 µg Ab, 40 µg BP | $361.00 | |||
Codanin-1 Antibody (G-1) AC | sc-365839 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Codanin-1 Antibody (G-1) HRP | sc-365839 HRP | 200 µg/ml | $322.00 | |||
Codanin-1 Antibody (G-1) FITC | sc-365839 FITC | 200 µg/ml | $336.00 | |||
Codanin-1 Antibody (G-1) PE | sc-365839 PE | 200 µg/ml | $349.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 488 | sc-365839 AF488 | 200 µg/ml | $364.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 546 | sc-365839 AF546 | 200 µg/ml | $364.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 594 | sc-365839 AF594 | 200 µg/ml | $364.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 647 | sc-365839 AF647 | 200 µg/ml | $364.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 680 | sc-365839 AF680 | 200 µg/ml | $364.00 | |||
Codanin-1 Antibody (G-1) Alexa Fluor® 790 | sc-365839 AF790 | 200 µg/ml | $364.00 |