Cochlioquinone A CAS: 32450-25-2
MF: C30H44O8
MW: 532.7
An antagonist of CCR5.

Cochlioquinone A (CAS 32450-25-2)

Cochlioquinone A | CAS 32450-25-2 is rated 5.0 out of 5 by 1.
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Application: An antagonist of CCR5
CAS Number: 32450-25-2
Purity: >99%
Molecular Weight: 532.7
Molecular Formula: C30H44O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. It has been found to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH ubiquinone reductase.


References

1. Jung, H.J., et al. 2003. Bioorg. Med. Chem. 11: 4743-4747. PMID: 14556789
2. Lee, H.B., et al. 2003. J. Antibiot. 56: 967-969. PMID: 14763563
3. Yoganathan, K., et al, 2004. J. Antibiot. 57: 59-63. PMID: 1503248

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Bipolaris leersia
Solubility :
Soluble in ethanol, methanol, DMF or DMSO.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
161747
SMILES :
CCC(C)C(C(C)C1=CC(=O)C2=C(C1=O)OC3(CCC4C(C3C2O)(CCC(O4)C(C)(C)O)C)C)OC(=O)C

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Certificate of Analysis

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Cochlioquinone A  Product Citations

See how others have used Cochlioquinone A. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 14556789  Jung, H. et al. 2003. Bioorg Med Chem. 30: 1563-1566.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Jung et al Jung et al. (PubMed ID 14556789) found Cochlioquinone A to be a potent anti-angionic agent. -SCBT Publication Review
Date published: 2015-01-11
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