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Cobalt(II) chloride hexahydrate (CAS 7791-13-1)

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Alternate Names:
Chlorek cobaltawy; Cobalt chloride hexahydrate; Cobaltous chloride, hexahydrate; Cobalt chloride, hexahydrate; cobalt chloride hydrate
Application:
Cobalt(II) chloride hexahydrate is an inducer of HIF-1 production used to study apoptotic effects in HepG2 cells
CAS Number:
7791-13-1
Purity:
≥98%
Molecular Weight:
237.93
Molecular Formula:
CoCl26H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cobalt(II) chloride hexahydrate is the most common form of this inorganic compound which is a deep rose color in the hydrated form. The dramatic color change of blue-purple Cobalt(II) chloride (sc-252623) to the rose color when hydrated makes Cobalt(II) chloride an excellent indicator for water in dessicants. As an inducer of HIF-1 production, Cobalt(II) chloride (CoCl2) has been used to study apoptotic effects in HepG2 cells. Also reported as a stabilizer for reconstitution of the radiopharmaceutical technetium-99m exametazime. CoCl2 has been used in studies to examine heat shock protein expression of inflamed skin.


Cobalt(II) chloride hexahydrate (CAS 7791-13-1) References

  1. Expression of heat shock proteins in heavy metal-provoked inflamed human skin.  |  Nordlind, K. 2002. Immunopharmacol Immunotoxicol. 24: 383-94. PMID: 12375735
  2. CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.  |  Piret, JP., et al. 2002. Ann N Y Acad Sci. 973: 443-7. PMID: 12485908
  3. The role of renal adenosine 3',5'-monophosphate in the control of erythropoietin production.  |  Rodgers, GM., et al. 1975. Am J Med. 58: 31-8. PMID: 163577
  4. Chromosomal aberrations induced by cobaltous chloride in mice in vivo.  |  Palit, S., et al. 1991. Biol Trace Elem Res. 29: 139-45. PMID: 1713470
  5. Synthesis, magnetic properties, and STM spectroscopy of cobalt(II) Cubanes [Co(II) (4)(Cl)(4)(HL)(4)].  |  Scheurer, A., et al. 2010. Chemistry. 16: 4784-92. PMID: 20306503
  6. Purification, crystallization and preliminary X-ray diffraction analysis of the effector protein MoHrip1 from Magnaporthe oryzae.  |  Zhang, C., et al. 2013. Acta Crystallogr Sect F Struct Biol Cryst Commun. 69: 460-2. PMID: 23545660
  7. Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines.  |  Mahey, S., et al. 2016. Springerplus. 5: 930. PMID: 27386374
  8. In vitro oxidative degradation of a spinal posterior dynamic stabilization device.  |  Lawless, BM., et al. 2018. J Biomed Mater Res B Appl Biomater. 106: 1237-1244. PMID: 28580771
  9. Trends in Patch Testing With the Mayo Clinic Standard Series, 2011-2015.  |  Veverka, KK., et al. 2018. Dermatitis. 29: 310-315. PMID: 30422883
  10. Enhanced Optical and Antibacterial Activity of Hydrothermally Synthesized Cobalt-Doped Zinc Oxide Cylindrical Microcrystals.  |  Khalid, A., et al. 2021. Materials (Basel). 14: PMID: 34207950
  11. Synthesis, Characterization, and Biological Activities of Novel Vanadium(IV) and Cobalt(II) Complexes.  |  Damena, T., et al. 2022. ACS Omega. 7: 4389-4404. PMID: 35155932
  12. Comparison of Aminoglycoside Antibiotics and Cobalt Chloride for Ablation of the Lateral Line System in Giant Danios.  |  Mekdara, PJ., et al. 2022. Integr Org Biol. 4: obac012. PMID: 35359665
  13. Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tracer in focal cerebral ischaemia.  |  Gartshore, G., et al. 1994. Eur J Nucl Med. 21: 913-23. PMID: 7995284

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cobalt(II) chloride hexahydrate, 25 g

sc-203004
25 g
$36.00

Cobalt(II) chloride hexahydrate, 100 g

sc-203004A
100 g
$92.00

Cobalt(II) chloride hexahydrate, 1 kg

sc-203004B
1 kg
$153.00

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Asked by: Isabel Marzo
Thank you for contacting Santa Cruz Biotechnology. For a price quote and ship date please email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2026-02-05
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Rated 5 out of 5 by from Various publications cite the use of Cobalt(II)Various publications cite the use of Cobalt(II) chloride hexahydrate, an Cobalt(II) chloride hexahydrate, to study apoptotic effects in HepG2 cells. -SCBT Publication Review
Date published: 2015-02-16
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Cobalt(II) chloride hexahydrate is rated 5.0 out of 5 by 1.
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