Molecular structure of Co 102862, CAS Number: 181144-66-1
Co 102862 (CAS 181144-66-1)
Alternate Names:
V102862; 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Application:
Co 102862 is an inhibitor of voltage-gated Na+ channels
CAS Number:
181144-66-1
Molecular Weight:
273.26
Molecular Formula:
C14H12FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Co 102862 is a state-dependent inhibitor of voltage-gated Na+ channels.
Co 102862 (CAS 181144-66-1) References
- In vivo metabolism and mass balance of 4-[4-fluorophenoxy]benzaldehyde semicarbazone in rats. | Ramu, K., et al. 2000. Drug Metab Dispos. 28: 1153-61. PMID: 10997933
- Voltage-gated sodium channels as therapeutic targets. | Clare, JJ., et al. 2000. Drug Discov Today. 5: 506-520. PMID: 11084387
- Development of a high-performance liquid chromatographic-tandem mass spectrometric method for the determination of pharmacokinetics of Co 102862 in mouse, rat, monkey and dog plasma. | Ramu, K., et al. 2000. J Chromatogr B Biomed Sci Appl. 749: 1-15. PMID: 11129068
- V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. | Ilyin, VI., et al. 2005. Br J Pharmacol. 144: 801-12. PMID: 15778702
- The metabolic profile of azimilide in man: in vivo and in vitro evaluations. | Riley, P., et al. 2005. J Pharm Sci. 94: 2084-95. PMID: 16052551
- A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels. | Bugianesi, RM., et al. 2006. Assay Drug Dev Technol. 4: 21-35. PMID: 16506886
- Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. | Ilyin, VI., et al. 2006. J Pharmacol Exp Ther. 318: 1083-93. PMID: 16728593
- Functional characterization of sodium channel blockers by membrane potential measurements in cerebellar neurons: prediction of compound preference for the open/inactivated state. | Kolok, S., et al. 2006. Neurochem Int. 49: 593-604. PMID: 16777267
- Voltage-gated sodium channels in neurological disorders. | Chahine, M., et al. 2008. CNS Neurol Disord Drug Targets. 7: 144-58. PMID: 18537643
- A Novel Metabolism-Related Signature as a Candidate Prognostic Biomarker for Hepatocellular Carcinoma. | Wang, Z., et al. 2021. J Hepatocell Carcinoma. 8: 119-132. PMID: 33758763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Co 102862, 10 mg | sc-203900 | 10 mg | $94.00 | |||
Co 102862, 50 mg | sc-203900A | 50 mg | $495.00 |