CNOT8 Antibody (1F11): sc-293395

CNOT8 Antibody (1F11) is a mouse monoclonal IgG2a kappa light chain antibody that detects CNOT8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CNOT8 antibody (1F11) is available as the non-conjugated format. CNOT8, also known as CCR4-NOT transcription complex subunit 8, CALIF, or POP2, is a 292 amino acid protein that plays a crucial role in regulating gene expression and mRNA degradation as part of the CCR4-NOT complex. This complex maintains cellular homeostasis and regulates various biological processes, including transcriptional regulation and mRNA turnover. CNOT8 regulates histone H3 lysine 4 methylation through a ubiquitin-dependent pathway, which controls gene expression and ensures proper cellular responses to environmental signals. CNOT8 is expressed ubiquitously and localizes to both nucleus and cytoplasm, highlighting its importance in diverse cellular functions. CNOT8 (1F11) antibody enables researchers to gain valuable insights into transcriptional regulation mechanisms and processes governing mRNA stability and degradation.

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CNOT8 Antibody (1F11) References:

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2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.  |  Albert, TK., et al. 2000. Nucleic Acids Res. 28: 809-17. PMID: 10637334
3. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.  |  Prévôt, D., et al. 2001. J Biol Chem. 276: 9640-8. PMID: 11136725
4. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.  |  Morel, AP., et al. 2003. J Cell Sci. 116: 2929-36. PMID: 12771185
5. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.  |  Dorfleutner, A., et al. 2007. Infect Immun. 75: 1484-92. PMID: 17178784
6. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.  |  Bogdan, JA., et al. 1998. Biochem J. 336 (Pt 2): 471-81. PMID: 9820826