CMV pp52 Antibody (CH16): sc-69744

CMV pp52 Antibody (CH16) is a mouse monoclonal IgG2b antibody that detects CMV pp52 protein of CMV origin by western blotting (WB) and immunofluorescence (IF). Anti-CMV pp52 antibody (CH16) is available as the non-conjugated monoclonal isotype antibody. Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a member of the herpes virus family, which includes other notable viruses such as herpes simplex virus types 1 and 2, Varicella Zoster Virus, and Epstein Barr virus. While CMV typically causes mild symptoms in healthy individuals, CMV can lead to severe complications in immunocompromised patients. CMV pp52 plays a crucial role as an accessory subunit of the viral DNA polymerase, facilitating the process of DNA replication, which is essential for viral propagation. CMV pp52′s function is particularly important because CMV pp52 enhances the efficiency of DNA synthesis, allowing the virus to replicate rapidly and establish infection. Additionally, CMV pp52 shares structural similarities with other DNA processivity factors, such as the UL42 protein from herpes simplex virus, highlighting CMV pp52′s significance in the viral life cycle and potential as a target for therapeutic intervention.

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CMV pp52 Antibody (CH16) References:

1. Role of cytomegalovirus infection in allograft rejection: a review of possible mechanisms.  |  Borchers, AT., et al. 1999. Transpl Immunol. 7: 75-82. PMID: 10544437
2. Cytomegalovirus infection in normal and immunocompromised humans. A review.  |  Drago, F., et al. 2000. Dermatology. 200: 189-95. PMID: 10828625
3. Congenital cytomegalovirus infection: review of the epidemiology and outcome.  |  Gaytant, MA., et al. 2002. Obstet Gynecol Surv. 57: 245-56. PMID: 11961482
4. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.  |  Appleton, BA., et al. 2006. J Biol Chem. 281: 5224-32. PMID: 16371349
5. Diagnosis of cutaneous cytomegalovirus infection: a review and report of a case.  |  Toome, BK., et al. 1991. J Am Acad Dermatol. 24: 860-7. PMID: 1646834
6. Congenital and perinatal cytomegalovirus infections.  |  Alford, CA., et al. 1990. Rev Infect Dis. 12 Suppl 7: S745-53. PMID: 2173104
7. Impact of cytomegalovirus infection on organ transplant recipients.  |  Rubin, RH. 1990. Rev Infect Dis. 12 Suppl 7: S754-66. PMID: 2173105
8. Cytomegalovirus infection following liver transplantation: review of the literature.  |  Kanj, SS., et al. 1996. Clin Infect Dis. 22: 537-49. PMID: 8852975
9. Quantitation of cytomegalovirus: methodologic aspects and clinical applications.  |  Boeckh, M. and Boivin, G. 1998. Clin Microbiol Rev. 11: 533-54. PMID: 9665982

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMV pp52 Antibody (CH16) has 14 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMV pp52 Antibody (CH16) Specifications

Alternate Product Name: CMV pp52

Product Clone Name: CH16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: CMV pp52

Epitope Species: CMV

Product Reactivity/Detection: pp52

Species Reactivity/Detection: CMV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for CMV pp52 Antibody (CH16): N/A