CMV ICP8 Antibody (CH167): sc-69746

CMV ICP8 Antibody (CH167) is a mouse monoclonal IgG2a antibody that detects the CMV ICP8 protein of CMV origin by western blotting (WB) and immunofluorescence (IF). Anti-CMV ICP8 antibody (CH167) is available as the non-conjugated format. Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a member of the herpes virus family, which includes other notable viruses such as herpes simplex virus types 1 and 2, Varicella Zoster Virus, and Epstein Barr virus. While CMV typically causes mild symptoms in healthy individuals, CMV can lead to severe complications in immunocompromised patients. CMV ICP8 protein, also referred to as UL57, SSB, or DB140, is an essential early, nonstructural gene product that is localized in the nucleus of infected cells. CMV ICP8 plays a critical role in viral replication as CMV ICP8 functions as a single-stranded DNA binding protein, which is vital for the replication of viral DNA. The ability of CMV ICP8 to bind to single-stranded DNA is crucial for the virus′s life cycle, as CMV ICP8 facilitates the unwinding of DNA during replication, thereby ensuring efficient viral propagation. Anti-CMV ICP8 antibody (CH167) is an invaluable tool for researchers studying CMV infection and its mechanisms, providing insights into the viral life cycle and potential therapeutic targets.

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CMV ICP8 Antibody (CH167) References:

1. The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10).  |  Ahn, JH., et al. 1999. J Virol. 73: 10458-71. PMID: 10559364
2. Multiple 5' ends of human cytomegalovirus UL57 transcripts identify a complex, cycloheximide-resistant promoter region that activates oriLyt.  |  Kiehl, A., et al. 2003. Virology. 314: 410-22. PMID: 14517093
3. [Expression of recombinant human cytomegalovirus fusion proteins pp150/MDBP fragments and its application].  |  Guo, DD., et al. 2006. Sheng Wu Gong Cheng Xue Bao. 22: 956-61. PMID: 17168319
4. Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2 (UL44 and UL57) detects active infection in patients with chronic fatigue syndrome.  |  Beqaj, SH., et al. 2008. J Clin Pathol. 61: 623-6. PMID: 18037660
5. Nucleotide sequence of a cytomegalovirus single-stranded DNA-binding protein gene: comparison with alpha- and gammaherpesvirus counterparts reveals conserved segments.  |  Anders, DG. 1990. J Gen Virol. 71 (Pt 10): 2451-6. PMID: 2172458
6. Location, transcript analysis, and partial nucleotide sequence of the cytomegalovirus gene encoding an early DNA-binding protein with similarities to ICP8 of herpes simplex virus type 1.  |  Anders, DG. and Gibson, W. 1988. J Virol. 62: 1364-72. PMID: 2831398
7. A cytomegalovirus protein with properties of herpes simplex virus ICP8: partial purification of the polypeptide and map position of the gene.  |  Kemble, GW., et al. 1987. J Virol. 61: 3143-51. PMID: 3041036
8. Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.  |  Pari, GS. and Anders, DG. 1993. J Virol. 67: 6979-88. PMID: 8230421
9. Genetic content of a 20.9 kb segment of human herpesvirus 6B strain Z29 spanning the homologs of human herpesvirus 6A genes U40-57 and containing the origin of DNA replication.  |  Lindquester, GJ., et al. 1997. Arch Virol. 142: 103-23. PMID: 9155876

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMV ICP8 Antibody (CH167) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMV ICP8 Antibody (CH167) Specifications

Alternate Product Name: CMV ICP8

Product Clone Name: CH167

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: CMV ICP8

Epitope Species: CMV

Product Reactivity/Detection: ICP8

Species Reactivity/Detection: CMV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CMV ICP8 Antibody (CH167): N/A