CMV gB Antibody (1-M-12): sc-52400

CMV gB Antibody (1-M-12) is a mouse monoclonal IgG1 antibody that detects CMV gB protein of CMV origin by western blotting (WB) and immunofluorescence (IF). Anti-CMV gB antibody (1-M-12) is available as the non-conjugated format. Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a member of the herpes virus family, which includes other notable viruses such as herpes simplex virus types 1 and 2, Varicella Zoster Virus, and Epstein Barr virus. These viruses can remain dormant in the body for extended periods, posing a risk of reactivation, particularly in immunocompromised individuals. CMV gB protein plays a crucial role in the viral life cycle, as CMV gB is an essential component of the virion envelope and is vital for the virus′s ability to infect host cells. CMV gB′s structure, characterized by multiple domains that facilitate interactions with host cell receptors, is critical for mediating viral entry and fusion. Additionally, CMV gB is one of the most immunogenic proteins encoded by the virus, with a significant portion of neutralizing antibodies targeting this protein, making CMV gB a key focus for vaccine development and therapeutic interventions.

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CMV gB Antibody (1-M-12) References:

1. Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells.  |  Jarvis, MA., et al. 2002. J Virol. 76: 5147-55. PMID: 11967330
2. Envelopment of human cytomegalovirus occurs by budding into Golgi-derived vacuole compartments positive for gB, Rab 3, trans-golgi network 46, and mannosidase II.  |  Homman-Loudiyi, M., et al. 2003. J Virol. 77: 3191-203. PMID: 12584343
3. Single human cytomegalovirus gB genotype shed in multiple sites at the time of diagnosis in renal transplant recipients.  |  Carraro, E. and Granato, CF. 2003. J Med Virol. 70: 240-3. PMID: 12696110
4. Role of PACS-1 in trafficking of human cytomegalovirus glycoprotein B and virus production.  |  Crump, CM., et al. 2003. J Virol. 77: 11105-13. PMID: 14512558
5. Antibody responses to rhesus cytomegalovirus glycoprotein B in naturally infected rhesus macaques.  |  Yue, Y., et al. 2003. J Gen Virol. 84: 3371-3379. PMID: 14645918
6. Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication.  |  Jarvis, MA., et al. 2004. J Virol. 78: 285-93. PMID: 14671110
7. Conserved cytoplasmic domain sequences mediate the ER export of VZV, HSV-1, and HCMV gB.  |  Heineman, TC., et al. 2004. Virology. 328: 131-41. PMID: 15380364
8. Presentation of three different viral peptides, HTLV-1 Tax, HCMV gB, and influenza virus M1, is determined by common structural features of the HLA-A2.1 molecule.  |  Utz, U., et al. 1992. J Immunol. 149: 214-21. PMID: 1607654
9. High expression of human cytomegalovirus (HCMV)-gB protein in cells infected with a vaccinia-gB recombinant: the importance of the gB protein in HCMV immunity.  |  Gönczöl, E., et al. 1991. Vaccine. 9: 631-7. PMID: 1659051

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMV gB Antibody (1-M-12) has 8 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMV gB Antibody (1-M-12) Specifications

Alternate Product Name: CMV gB

Product Clone Name: 1-M-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CMV gB

Epitope Species: CMV

Product Reactivity/Detection: human CMV gB (glycoprotein B)

Species Reactivity/Detection: CMV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for CMV gB Antibody (1-M-12): N/A