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CMP-Sialic Acid, Monosodium Salt (CAS 3063-71-6)

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Alternate Names:
CMP-N-Acetylneuraminic Acid, Na
Application:
CMP-Sialic Acid, Monosodium Salt is a toxin/gonococci protector; blood regulator
CAS Number:
3063-71-6
Purity:
≥85%
Molecular Weight:
636.43
Molecular Formula:
C20H30N4O16P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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CMP-sialic acid, Monosodium salt is the active form of sialic acid. In mammalian cells it may act to be required for the biosynthesis of sialic acid-containing complex carbohydrates. Loss of CMP sialic acid, Monosodium salt production or the feed back inhibitor of CMP-sialic acid has lead to gram scale production of sialic acid by GLCNE (GNE, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). The compound has demonstrated the ability to neutralize various toxins through masking binding sites. CMP-sialic acid, Monosodium salt has also provided protection against gonococci by siaylation of Gal beta 1-4GlcNAc group. Catalyzed through a surface sialyl-transferase, CMP-Sialic Acid, Monosodium Salt enhanced the responsiveness of insulin. The compound has also displayed function in blood protein half-life regulation, protection against glycoprotein lysis and cellular adhesion. CMP-Sialic Acid, Monosodium Salt is a substrate of Sialyltransferase.


CMP-Sialic Acid, Monosodium Salt (CAS 3063-71-6) References

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  2. A transgenic insect cell line engineered to produce CMP-sialic acid and sialylated glycoproteins.  |  Aumiller, JJ., et al. 2003. Glycobiology. 13: 497-507. PMID: 12626399
  3. The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule.  |  Bork, K., et al. 2005. FEBS Lett. 579: 5079-83. PMID: 16137682
  4. The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.  |  Zhao, W., et al. 2006. J Biol Chem. 281: 31106-18. PMID: 16923816
  5. Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi.  |  Melkerson-Watson, LJ. and Sweeley, CC. 1991. J Biol Chem. 266: 4448-57. PMID: 1999428
  6. CMP-sialic acid, the sole sialosyl donor, is intra-axonally transported.  |  Igarashi, M., et al. 1985. FEBS Lett. 192: 239-42. PMID: 2415391
  7. Diverse subcellular localizations of the insect CMP-sialic acid synthetases.  |  Di, W., et al. 2017. Glycobiology. 27: 329-341. PMID: 27986833
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  9. Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family.  |  Volkers, G., et al. 2018. ACS Chem Biol. 13: 2320-2328. PMID: 30015474
  10. Role of sialic acid in insulin action and the insulin resistance of diabetes mellitus.  |  Salhanick, AI. and Amatruda, JM. 1988. Am J Physiol. 255: E173-9. PMID: 3407769
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  13. Sialylation of lipopolysaccharide by CMP-NANA in viable gonococci is enhanced by low Mr material released from blood cell extracts but not by some UDP sugars.  |  Parsons, NJ., et al. 1994. Microb Pathog. 16: 413-21. PMID: 7830528

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CMP-Sialic Acid, Monosodium Salt, 1 mg

sc-202549
1 mg
$112.00

CMP-Sialic Acid, Monosodium Salt, 5 mg

sc-202549A
5 mg
$367.00