Molecular structure of Clozapine-d8, CAS Number: 1185053-50-2
Clozapine-d8 (CAS 1185053-50-2)
Alternate Names:
Liponex-d8
Application:
Clozapine-d8 is a deuterium-labeled version of Clozapine, a selective compound for D4-dopamine and 5HT2 serotonin receptors
CAS Number:
1185053-50-2
Purity:
≥98%
Molecular Weight:
334.87
Molecular Formula:
C18H11D8ClN4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clozapine-d8 is a deuterium-labeled version of the compound clozapine (sc-200402). Substitution with deuterium may enhance the metabolic stability of the molecule since the C-D bond is stronger and less susceptible to enzymatic breakdown than the C-H bond. This modification may lead to differences in the compound′s kinetics. By tracking the deuterated version and the non-deuterated compound, researchers can gain insight into how the compound is handled in vivo and identify metabolic pathways. Clozapine binds preferentially to D4DR (D4-dopamine) and SR-2 (5HT2-5-hydroxytryptamine receptor) and acts as a weak D1 and D2 antagonist. Clozapine has also been reported to bind to SR-2 (5HT2), SR-6 (5HT6), and SR-7 (5HT7 receptors).
Clozapine-d8 (CAS 1185053-50-2) References
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- Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography. | Rosland, M., et al. 2007. Drug Dev Ind Pharm. 33: 1158-66. PMID: 17963117
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- Validated GC/MS method for the simultaneous determination of clozapine and norclozapine in human plasma. Application in psychiatric patients under clozapine treatment. | Vardakou, I., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2327-32. PMID: 20674521
- A novel approach to quantitative LC-MS/MS: therapeutic drug monitoring of clozapine and norclozapine using isotopic internal calibration. | Couchman, L., et al. 2013. Anal Bioanal Chem. 405: 9455-66. PMID: 24091736
- High-throughput characterization of small and large molecules using only a matrix and the vacuum of a mass spectrometer. | Woodall, DW., et al. 2015. Anal Chem. 87: 4667-74. PMID: 25756217
- Drug detection and quantification directly from tissue using novel ionization methods for mass spectrometry. | Wang, B., et al. 2015. Eur J Mass Spectrom (Chichester). 21: 201-10. PMID: 26307700
- Bioconcentration of two basic pharmaceuticals, verapamil and clozapine, in fish. | Nallani, GC., et al. 2016. Environ Toxicol Chem. 35: 593-603. PMID: 26753615
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Inhibitor of:
D2DR, D4DR, SR-2A, SR-2C, SR-6, and SR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clozapine-d8, 1 mg | sc-217944 | 1 mg | $480.00 | |||
Clozapine-d8, 10 mg | sc-217944A | 10 mg | $2400.00 |