Date published: 2025-12-18

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Cloxacillin sodium monohydrate (CAS 7081-44-9)

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Alternate Names:
Bactopen; Cloxapen; Cloxypen; Ekvacillin; Orbenin; Methocillin-S
Application:
Cloxacillin sodium is a semi-synthetic antibiotic related to penicillin
CAS Number:
7081-44-9
Purity:
>94%
Molecular Weight:
475.88
Molecular Formula:
C19H17ClN3NaO5S•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cloxacillin sodium monohydrate is a narrow-spectrum beta-lactam antibiotic that belongs to the penicillin group. It is effective against certain gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae. Cloxacillin sodium monohydrate works by inhibiting the synthesis of bacterial cell walls, leading to the death of the bacteria. This antibiotic selectively kills gram-positive bacteria and study their mechanisms of resistance in laboratory.It is applied in microbiology and biochemistry experiments to isolate and identify specific bacterial strains. Cloxacillin sodium monohydrate is useful for studying antibiotic resistance and the development of new antimicrobial agents. Its specificity for gram-positive bacteria makes it a useful reagent for investigating the molecular mechanisms of bacterial cell wall synthesis and the action of beta-lactam antibiotics.


Cloxacillin sodium monohydrate (CAS 7081-44-9) References

  1. Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli.  |  Nishino, K., et al. 2011. J Antimicrob Chemother. 66: 291-6. PMID: 21088020
  2. Quinoline Antimalarials Increase the Antibacterial Activity of Ampicillin.  |  Olateju, OA., et al. 2021. Front Microbiol. 12: 556550. PMID: 34149629
  3. Pharmaceutical Functionalization of Monomeric Ionic Liquid for the Preparation of Ionic Graft Polymer Conjugates.  |  Mazur, A., et al. 2022. Int J Mol Sci. 23: PMID: 36499061
  4. Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis.  |  Bellouard, R., et al. 2023. J Antimicrob Chemother. 78: 965-974. PMID: 36760090
  5. Residue Concentrations of Cloxacillin in Milk after Intramammary Dry Cow Treatment Considering Dry Period Length.  |  Fischer-Tenhagen, C., et al. 2023. Animals (Basel). 13: PMID: 37627348
  6. Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial.  |  Grillo, S., et al. 2023. Nat Med. 29: 2518-2525. PMID: 37783969
  7. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort.  |  Herrera-Hidalgo, L., et al. 2023. Int J Infect Dis. 137: 134-143. PMID: 37926195
  8. Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis.  |  Vander Elst, N., et al. 2024. Appl Microbiol Biotechnol. 108: 118. PMID: 38204128
  9. Mechanism of substrate-induced inactivation of beta-lactamase I.  |  Kiener, PA., et al. 1980. Eur J Biochem. 109: 575-80. PMID: 6773776
  10. Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme.  |  Rasmussen, BA., et al. 1994. Antimicrob Agents Chemother. 38: 2078-85. PMID: 7811022
  11. Susceptibility of Staphylococcus aureus and Staphylococcus epidermidis to 65 antibiotics.  |  Sabath, LD., et al. 1976. Antimicrob Agents Chemother. 9: 962-9. PMID: 938025

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cloxacillin sodium monohydrate, 1 g

sc-205261
1 g
$66.00

Cloxacillin sodium monohydrate, 5 g

sc-205261A
5 g
$255.00

Cloxacillin sodium monohydrate, 25 g

sc-205261B
25 g
$797.00

Cloxacillin sodium monohydrate, 100 g

sc-205261C
100 g
$1533.00

Cloxacillin sodium monohydrate, 250 g

sc-205261D
250 g
$3060.00