Clorgyline hydrochloride (CAS 17780-75-5)
See product citations (2)
QUICK LINKS
Clorgyline hydrochloride is a reversible and selective inhibitor of the enzyme monoamine oxidase A (MAO-A). It functions by binding to the active site of MAO-A, preventing the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine. This inhibition leads to an increase in the levels of these neurotransmitters in the synaptic cleft, ultimately affecting neurotransmission. By modulating the levels of these neurotransmitters, Clorgyline hydrochloride can be used to study the role of MAO-A in various physiological and pathological processes. Its mechanism of action involves targeting and inhibiting the activity of MAO-A. Clorgyline Hydrochloride′s function in experimental applications involves elucidating the role of MAO-A in neurotransmission and its potential implications in various biological processes.
Clorgyline hydrochloride (CAS 17780-75-5) References
- Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives. | Inoue, H., et al. 1999. J Pharmacol Exp Ther. 291: 856-64. PMID: 10525109
- Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. | Honda, M., et al. 2003. Eur J Pharmacol. 482: 155-61. PMID: 14660017
- Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. | Lee, MG., et al. 2006. Chem Biol. 13: 563-7. PMID: 16793513
- Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. | Guillem, K., et al. 2006. Eur J Neurosci. 24: 3532-40. PMID: 17229101
- Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. | Nishizawa, K., et al. 2007. Biol Pharm Bull. 30: 1758-62. PMID: 17827735
- Expression of monoamine oxidase B activity in astrocytes of senile plaques. | Nakamura, S., et al. 1990. Acta Neuropathol. 80: 419-25. PMID: 2239154
- Selegiline reverses aβ₂₅₋₃₅-induced cognitive deficit in male mice. | Pazini, AM., et al. 2013. Neurochem Res. 38: 2287-94. PMID: 24005822
- Effects of combined treatment with clorgyline and selegiline on extracellular noradrenaline and serotonin levels. | Kitaichi, Y., et al. 2012. Acta Neuropsychiatr. 24: 369-73. PMID: 25287180
- Effect of monoamine oxidase inhibitors on codeine disposition and pentobarbitone sleep-times in the rat. | Findlay, JW., et al. 1981. J Pharm Pharmacol. 33: 45-7. PMID: 6114154
- Reduced accumulation in brain of orally ingested beta-phenethylamine after inhibition of type A monoamine oxidase in the rat. | Keane, PE. and Benedetti, MS. 1981. J Pharm Pharmacol. 33: 800-2. PMID: 6121858
- Behavioural response to SKF 38393 and quinpirole following chronic antidepressant treatment. | Allison, K., et al. 1995. Eur J Pharmacol. 277: 139-44. PMID: 7493601
- Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. | Shih, JC., et al. 1998. J Neural Transm Suppl. 52: 1-8. PMID: 9564602
- The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. | Figueiredo, IV., et al. 1998. J Auton Pharmacol. 18: 123-8. PMID: 9730267
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clorgyline hydrochloride, 50 mg | sc-214749 | 50 mg | $128.00 | |||
Clorgyline hydrochloride, 100 mg | sc-214749A | 100 mg | $214.00 |