Molecular structure of Clopidogrel Carboxylic Acid, CAS Number: 144457-28-3
Clopidogrel Carboxylic Acid (CAS 144457-28-3)
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Alternate Names:
(S)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic Acid
Application:
Clopidogrel Carboxylic Acid is a metabolite of clopidogrel
CAS Number:
144457-28-3
Molecular Weight:
307.80
Molecular Formula:
C15H14ClNO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clopidogrel Carboxylic Acid is a metabolite of clopidogrel. Clopidogrel Carboxylic Acid is formed in the liver through a series of enzymatic reactions. Clopidogrel carboxylic acid is an active thiol metabolite that irreversibly binds to the P2Y12 class of ADP receptors on platelets, inhibiting platelet aggregation and reducing the risk of thrombotic events. This metabolite is an important component of the pharmacological action of clopidogrel and contributes to its antiplatelet effects. Clopidogrel carboxylic acid is further metabolized and eliminated.
Clopidogrel Carboxylic Acid (CAS 144457-28-3) References
- Influence of number of calibration standards within a defined range on pharmacokinetic disposition-case studies with omeprazole and clopidogrel carboxylic acid. | D'Souza, HJ., et al. 2010. Biomed Chromatogr. 24: 544-9. PMID: 19739245
- Capillary zone electrophoresis method for determination of (+)-S clopidogrel carboxylic acid metabolite in human plasma and urine designed for biopharmaceutic studies. | Karaźniewicz-Łada, M., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 1013-8. PMID: 20346740
- Development and validation of an HPLC-MS/MS method to quantify clopidogrel acyl glucuronide, clopidogrel acid metabolite, and clopidogrel in plasma samples avoiding analyte back-conversion. | Silvestro, L., et al. 2011. Anal Bioanal Chem. 401: 1023-34. PMID: 21656175
- HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples. | Karaźniewicz-Łada, M., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 911: 105-12. PMID: 23217313
- Effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of clopidogrel in rats. | Chen, F., et al. 2015. Xenobiotica. 45: 1122-8. PMID: 26068527
- Metabolic Interaction Potential between Clopidogrel and Sulfonylurea Antidiabetic Agents: Effects on Clopidogrel Bioactivation. | Shao, H., et al. 2016. Pharmacology. 97: 18-24. PMID: 26569597
- Evaluation of Clopidogrel Conjugation Metabolism: PK Studies in Man and Mice of Clopidogrel Acyl Glucuronide. | Savu, SN., et al. 2016. Drug Metab Dispos. 44: 1490-7. PMID: 27402727
- Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. | Lyngby, JG., et al. 2017. J Vet Cardiol. 19: 384-395. PMID: 28602635
- Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions . | Kahma, H., et al. 2018. Drug Metab Dispos. 46: 141-150. PMID: 29138287
- Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate. | Ji, JZ., et al. 2018. Biopharm Drug Dispos. 39: 88-98. PMID: 29240983
- Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study. | Malkawi, M., et al. 2019. J Feline Med Surg. 21: 951-958. PMID: 30427274
- Interspecies variation of clopidogrel hydrolysis in liver microsomes from various mammals. | Wang, YQ., et al. 2020. Chem Biol Interact. 315: 108871. PMID: 31669218
- Coding SNPs in hsa-miR-1343-3p and hsa-miR-6783-3p target sites of CYP2C19 modulates clopidogrel response in individuals with cardiovascular diseases. | Sharma, AR., et al. 2020. Life Sci. 245: 117364. PMID: 32001263
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clopidogrel Carboxylic Acid, 5 mg | sc-217938 | 5 mg | $500.00 |