Date published: 2025-10-14

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Clopidogrel Acyl-β-D-glucuronide (CAS 1314116-53-4 (S-isomer))

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Alternate Names:
1-[α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate] β-D-Glucopyranuronic Acid
Application:
Clopidogrel Acyl-β-D-glucuronide is a Clopidogrel metabolite
CAS Number:
1314116-53-4 (S-isomer)
Molecular Weight:
483.92
Molecular Formula:
C21H22ClNO8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clopidogrel Acyl-β-D-glucuronide is a metabolite of clopidogrel that is utilized in research to understand chemical metabolism and excretion pathways. As a glucuronide conjugate, it represents a phase II metabolic product, where the parent compound is linked to glucuronic acid, increasing its water solubility for renal excretion. Studies involving Clopidogrel Acyl-β-D-glucuronide focus on the activity of enzymes such as UDP-glucuronosyltransferases (UGTs), which mediate the conjugation process. Researchers also use this compound to investigate the kinetics of clopidogrel, analyzing how it is processed in the body and how its metabolites are distributed and eliminated. Additionally, Clopidogrel Acyl-β-D-glucuronide serves as a reference standard in analytical assays designed to measure the levels of clopidogrel metabolites in biological samples.


Clopidogrel Acyl-β-D-glucuronide (CAS 1314116-53-4 (S-isomer)) References

  1. Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy.  |  Wang, ZY., et al. 2015. Ther Clin Risk Manag. 11: 449-67. PMID: 25848291
  2. Development of a sensitive and fast UHPLC-MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma.  |  Hua, W., et al. 2015. Bioanalysis. 7: 1471-82. PMID: 26168254
  3. Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.  |  Itkonen, MK., et al. 2018. Clin Pharmacol Ther. 104: 495-504. PMID: 29171020
  4. Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood.  |  Ji, JZ., et al. 2018. Drug Metab Dispos. 46: 151-154. PMID: 29196299
  5. Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.  |  Itkonen, MK., et al. 2019. Drug Metab Dispos. 47: 377-385. PMID: 30630815
  6. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.  |  Kahma, H., et al. 2019. Drug Metab Dispos. 47: 436-443. PMID: 30709838
  7. Interspecies variation of clopidogrel hydrolysis in liver microsomes from various mammals.  |  Wang, YQ., et al. 2020. Chem Biol Interact. 315: 108871. PMID: 31669218
  8. P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.  |  Ji, JZ., et al. 2021. Biochem Pharmacol. 183: 114313. PMID: 33137324
  9. Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.  |  Ge, PX., et al. 2021. Life Sci. 279: 119268. PMID: 33626394
  10. An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity.  |  Kahma, H., et al. 2021. Eur J Pharm Sci. 162: 105810. PMID: 33753217
  11. Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.  |  Jiang, LP., et al. 2022. Br J Pharmacol. 179: 46-64. PMID: 34415054
  12. Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1.  |  Jiang, LP., et al. 2023. J Thromb Haemost.. PMID: 36738827

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clopidogrel Acyl-β-D-glucuronide, 1 mg

sc-217936
1 mg
$970.00