Clonidine hydrochloride CAS: 4205-91-8
MF: C9H9CI2N3•HCl
MW: 266.55
An antihypertensive α2-adrenergic receptor agonist.

Clonidine hydrochloride (CAS 4205-91-8)

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Alternate Names: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Application: Clonidine hydrochloride is an antihypertensive α2-adrenergic receptor agonist
CAS Number: 4205-91-8
Purity: 98%
Molecular Weight: 266.55
Molecular Formula: C9H9CI2N3•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Clonidine hydrochloride is an antihypertensive α2A-AR (α2-AR adrenergic receptor) agonist and I1 imidazoline receptor ligand. This compound acts on α-1 adrenoceptors as a partial agonist, causing relaxation of the mesenteric artery pre-contracted with norepinephrine or contraction of preparations pre-contracted with endothelin. Clonidine may hyperpolarize the plasma membrane and open K+ channels of mesenteric artery by affecting α-2 adrenoceptors. Clonidine hydrochloride is an activator of Nischarin.


References

1. Ernsberger, P., et al. 1987. Eur. J. Pharmacol. 134: 1-13. PMID: 3030779
2. Felsen, D., et al. 1987. Eur. J. Pharmacol. 142: 453-455. PMID: 3480808
3. Greney, H., et al. 1994. Eur. J. Pharmacol. 265: R1-R2. PMID: 7883019
4. Silva, E.G., et al. 1996. J. Pharmacol. Exp. Ther. 277: 872-876. PMID: 8627569
5. Head, G.A., et al. 1998. J. Auton. Nerv. Syst. 72: 163-169. PMID: 9851565
6. Eglen, R.M., et al. 1998. Trends Pharmacol. Sci. 19: 381-390. PMID: 9786027
7. Khan, Z.P., et al. 1999. Anaesthesia. 54: 146-165. PMID: 10215710
8. Schneider, J.S., et al. 2010. Behav Brain Res. 21: 236-239. PMID: 20347876
9. Hollman, G.A., et al. 2010. Int J Pediatr Endocrinol. : 103742. PMID: 20368793

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO (75 mM), methanol, chloroform (slightly), and dehydrated alcohol.
pH :
4.0
Storage :
Store at 4° C
Melting Point :
312° C (lit.)
Boiling Point :
319.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 8.2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NJ2490000
PubChem CID :
20179
Merck Index :
14: 2390
MDL Number :
MFCD00036705
EC Number :
224-121-5
Beilstein Registry :
4163525
SMILES :
C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Clonidine hydrochloride (CAS 4205-91-8)  Product Citations

See how others have used Clonidine hydrochloride (CAS 4205-91-8). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 30731136  Höllerhage, M. et al. 2019. Neuropharmacology. 149: 13-26.

PMID: # 29633624  2018. Can. J. Physiol. Pharmacol. 96: 845-849.

PMID: # 27929541  Nizari, S. et al. 2016. Cell Death Dis. 7: e2514.

PMID: # 20368793  Hollman, GA. et al. 2010. Int J Pediatr Endocrinol. 2010: -.

PMID: # 20347876  Schneider, JS. et al. 2010. Behav. Brain Res. 211: 236-239.

PMID: # 10215710  Khan, ZP. et al. 1999. Anaesthesia. 54: 146-165.

PMID: # 9851565  Head, GA. et al. 1998. J. Auton. Nerv. Syst. 72: 163-169.

PMID: # 9786027  Eglen, RM. et al. 1998. Trends Pharmacol. Sci. 19: 381-390.

PMID: # 8627569  Silva, EG. et al. 1996. J. Pharmacol. Exp. Ther. 277: 872-876.

PMID: # 7883019  Greney, H. et al. 1994. Eur. J. Pharmacol. 265: R1-R2.

Citations 1 to 10 of 11 total
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