Date published: 2026-4-30

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Clofoctol (CAS 37693-01-9)

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Datasheets
Alternate Names:
2-[(2,4-Dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)phenol;2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)phenol;2-(2,4-Dichlorobenzyl)-4-(2,4,4-trimethyl-2-pentyl)phenol; Clofoctol; Octofene
CAS Number:
37693-01-9
Molecular Weight:
365.34
Molecular Formula:
C21H26Cl2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clofoctol is a distinctive chemical compound primarily utilized in research to study its unique antibacterial mechanism. It functions by targeting the bacterial cell membrane, particularly disrupting its integrity, which leads to the inhibition of bacterial growth and viability. This mechanism is critical for understanding the interactions between bacterial cell structures and synthetic compounds. In scientific studies, Clofoctol is employed to investigate its efficacy against various gram-positive bacteria, providing insights into membrane dynamics and the potential for targeting bacterial membranes. Researchers also use Clofoctol to explore the modulation of bacterial gene expression related to membrane synthesis and repair, contributing to a broader understanding of bacterial adaptation to hostile environments. Additionally, the compound′s ability to disrupt bacterial membranes without affecting human cells makes it an excellent model for studying selective toxicity. These studies are vital for advancing our knowledge of bacterial physiology and could lead to the development of new strategies for managing bacterial populations in environmental and industrial settings. Through these applications, Clofoctol enhances our understanding of microbial ecology and the potential for targeted bacterial control.


Clofoctol (CAS 37693-01-9) References

  1. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.  |  Wang, M., et al. 2014. Br J Pharmacol. 171: 4478-89. PMID: 24903412
  2. Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library.  |  Niu, H., et al. 2015. Antibiotics (Basel). 4: 179-87. PMID: 27025620
  3. Identification and Ranking of Clinical Compounds with Activity Against Log-phase Growing Uropathogenic Escherichia coli.  |  Niu, H., et al. 2020. Curr Drug Discov Technol. 17: 191-196. PMID: 30088449
  4. Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa.  |  D'Angelo, F., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 30201815
  5. Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach.  |  Cheng, AN., et al. 2018. EBioMedicine. 36: 241-251. PMID: 30293817
  6. Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways.  |  Fan, L., et al. 2018. Cancer Manag Res. 10: 4817-4829. PMID: 30425575
  7. Comparative Emergence of Resistance to Clofoctol, Erythromycin, and Amoxicillin against Community-Acquired Bacterial Respiratory Tract Pathogens in Italy.  |  Scaglione, F., et al. 2018. Chemotherapy. 63: 330-337. PMID: 30909281
  8. Identification of FDA-Approved Drugs with Activity against Stationary Phase Bartonella henselae.  |  Li, T., et al. 2019. Antibiotics (Basel). 8: PMID: 31035691
  9. The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13.  |  Hu, Y., et al. 2019. J Clin Invest. 129: 3072-3085. PMID: 31112526
  10. In vitro Activity of Antivirulence Drugs Targeting the las or pqs Quorum Sensing Against Cystic Fibrosis Pseudomonas aeruginosa Isolates.  |  Collalto, D., et al. 2022. Front Microbiol. 13: 845231. PMID: 35547141
  11. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.  |  Belouzard, S., et al. 2022. PLoS Pathog. 18: e1010498. PMID: 35587469
  12. Synergistic Activity of Colistin in Combination with Clofoctol against Colistin Resistant Gram-Negative Pathogens.  |  Collalto, D., et al. 2023. Microbiol Spectr. 11: e0427522. PMID: 36802038
  13. The pharmacokinetic profile of clofoctol in rat plasma and tissues after oral and rectal administration.  |  Alessandrì, MG., et al. 1986. Drugs Exp Clin Res. 12: 343-7. PMID: 3720520
  14. Synthesis and Characterization of New-Type Soluble β-Substituted Zinc Phthalocyanine Derivative of Clofoctol.  |  Dridi, S., et al. 2023. Molecules. 28: PMID: 37241842

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clofoctol, 100 mg

sc-507221
100 mg
$240.00