Molecular structure of Clobetasol Propionate, CAS Number: 25122-46-7
Clobetasol Propionate (CAS 25122-46-7)
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Application:
Clobetasol Propionate is an anti-inflammatory, antipruritic and vasoconstrictive agent
CAS Number:
25122-46-7
Purity:
≥98%
Molecular Weight:
466.98
Molecular Formula:
C25H32ClFO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clobetasol Propionate is widely used in biochemical research to understand the mechanisms of anti-inflammatory action at the cellular level. In studies focusing on skin biology, it is used to explore the regulation of inflammatory mediators and cytokine production. Researchers utilize Clobetasol Propionate to investigate its effects on various signaling pathways, including those involved in cellular proliferation and differentiation. Its role in gene expression modulation is also a key area of study, particularly in understanding how it influences transcription factors within cells. Furthermore, Clobetasol Propionate is used in dermatological research to examine cellular responses in different models of skin inflammation.
Clobetasol Propionate (CAS 25122-46-7) References
- Clobetasol propionate in the treatment of premenarchal vulvar lichen sclerosus. | Smith, YR. and Quint, EH. 2001. Obstet Gynecol. 98: 588-91. PMID: 11576572
- Bioavailability of clobetasol propionate in different vehicles. | Franz, TJ., et al. 2003. Skin Pharmacol Appl Skin Physiol. 16: 212-6. PMID: 12784060
- Microparticulate based topical delivery system of clobetasol propionate. | Badıllı, U., et al. 2011. AAPS PharmSciTech. 12: 949-57. PMID: 21748539
- Chromatographic method for clobetasol propionate determination in hair follicles and in different skin layers. | Ângelo, T., et al. 2017. Biomed Chromatogr. 31: PMID: 27502902
- Clobetasol-induced milia. | Iacobelli, D., et al. 1989. J Am Acad Dermatol. 21: 215-7. PMID: 2768571
- Clobetasol propionate enhances neural stem cell and oligodendrocyte differentiation. | Shi, W., et al. 2019. Exp Ther Med. 18: 1258-1266. PMID: 31363370
- Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. | Wright, WC., et al. 2020. J Med Chem. 63: 1415-1433. PMID: 31965799
- Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus. | Özkur, E., et al. 2019. Postepy Dermatol Alergol. 36: 722-726. PMID: 31998001
- Development and characterisation of clobetasol propionate loaded Squarticles as a lipid nanocarrier for treatment of plaque psoriasis. | Dadwal, A., et al. 2020. J Microencapsul. 37: 341-354. PMID: 32293928
- Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. | Lu, YT., et al. 2020. J Pharm Biomed Anal. 186: 113322. PMID: 32380355
- Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation. | Kumar, S., et al. 2021. Mater Sci Eng C Mater Biol Appl. 119: 111605. PMID: 33321649
- Clobetasol propionate 0.05% under occlusion for alopecia areata: Clinical effect and influence on intraocular pressure. | Nomiyama, T. and Katoh, N. 2021. Australas J Dermatol. 62: e262-e264. PMID: 33393075
- Efficacy and Safety of Novel Formulation of Clobetasol Propionate 0.025% Cream in Indian Moderate-to-Severe Psoriasis Patients: Phase-2a, Randomized 3-Arm Study. | Sidgiddi, S., et al. 2021. Dermatol Ther (Heidelb). 11: 1717-1732. PMID: 34453262
- Bimatoprost versus Clobetasol Propionate in Scalp Alopecia Areata: A Prospective Non-Randomized Open-Label Clinical Trial. | Bhusal, M., et al. 2023. Indian Dermatol Online J. 14: 221-225. PMID: 37089845
- Allergens in Common Brands of Clobetasol. | Ramani, L., et al. 2023. J Drugs Dermatol. 22: 491-495. PMID: 37133477
Inhibitor of:
KRTAP20-1, KRTAP9-2, NG2, and Tenascin-X.Activator of:
AGP-1, Lce1i, MOG, and PMP22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clobetasol Propionate, 100 mg | sc-204692 | 100 mg | $52.00 | |||
Clobetasol Propionate, 500 mg | sc-204692A | 500 mg | $160.00 |