CLIM-2 Antibody (C-3): sc-365245
- CLIM-2 Antibody (C-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-27 at the N-terminus of CLIM-2 of human origin
- recommended for detection of CLIM-2 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, porcine and avian
- TransCruz reagent for ChIP application (sc-365245 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CLIM-2 Antibody (C-3) for WB applications. These reagents are now offered in bundles with CLIM-2 Antibody (C-3) (see ordering information below).
CLIM-2 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects CLIM-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLIM-2, also known as nuclear LIM interactor, plays a crucial role in forming transcriptional regulatory complexes by interacting with LIM-only proteins, such as LMO1 and LMO2, which are essential for gene expression regulation. CLIM-2 is primarily located in the nucleus, where CLIM-2 facilitates the assembly of heteromeric LIM complexes, enhancing nuclear retention of LIM proteins and promoting transcriptional activity. This localization ensures LIM proteins can effectively regulate gene expression in response to cellular signals, influencing processes such as cell differentiation and development. CLIM-2′s ability to interact with various LIM proteins underscores CLIM-2′s importance in the intricate network of transcriptional regulation, particularly in neuronal development and function. With specificity and versatility, anti-CLIM-2 antibody (C-3) serves as an invaluable tool for researchers investigating LIM proteins′ roles in various biological processes.
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CLIM-2 Antibody (C-3) References:
- Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells. | Kiefer, CM., et al. 2011. Blood. 118: 6200-8. PMID: 22010104
- Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. | Costello, I., et al. 2015. Genes Dev. 29: 2108-22. PMID: 26494787
- Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons. | Kim, S., et al. 2016. Stem Cells Dev. 25: 986-94. PMID: 27171818
- The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. | Espiritu, EB., et al. 2018. Sci Rep. 8: 16029. PMID: 30375416
- The transcriptional co-regulator LDB1 is required for brown adipose function. | Kepple, JD., et al. 2021. Mol Metab. 53: 101284. PMID: 34198011
- Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells. | Park, CG., et al. 2022. Cells. 11: PMID: 35805116
- The Ldb1 transcriptional co-regulator is required for establishment and maintenance of the pancreatic endocrine lineage. | Toren, E., et al. 2022. FASEB J. 36: e22460. PMID: 35881062
- Enhancer looping protein LDB1 regulates hepatocyte gene expression by cooperating with liver transcription factors. | Liu, G., et al. 2022. Nucleic Acids Res. 50: 9195-9211. PMID: 36018801
- LDB1 establishes multi-enhancer networks to regulate gene expression. | Aboreden, NG., et al. 2025. Mol Cell. 85: 376-393.e9. PMID: 39721581
- Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. | Agulnick, AD., et al. 1996. Nature. 384: 270-2. PMID: 8918878
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLIM-2 Antibody (C-3) | sc-365245 | 200 µg/ml | $322.00 | |||
CLIM-2 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-537791 | 200 µg Ab; 10 µg BP | $361.00 | |||
CLIM-2 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-535178 | 200 µg Ab; 40 µg BP | $361.00 | |||
CLIM-2 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-545355 | 200 µg Ab; 20 µg BP | $361.00 | |||
CLIM-2 (C-3) Neutralizing Peptide | sc-365245 P | 100 µg/0.5 ml | $69.00 | |||
CLIM-2 Antibody (C-3) X | sc-365245 X | 200 µg/0.1 ml | $322.00 |