CLIC6 Antibody (C-3): sc-515339
- CLIC6 Antibody (C-3) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 327-351 within an internal region of CLIC6 of mouse origin
- recommended for detection of CLIC6 of mouse origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for CLIC6 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with CLIC6 Antibody (C-3) (see ordering information below).
CLIC6 Antibody (C-3) is a mouse monoclonal IgG3 antibody that detects chloride intracellular channel 6 (CLIC6) in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLIC6 is a crucial protein that functions as a probable chloride ion channel, playing a significant role in the regulation of chloride ion transport, particularly in water-secreting cells. This regulation is vital for maintaining cellular homeostasis and fluid balance, which is essential for various physiological processes. Notably, CLIC6 is distinguished from other members of the chloride channel family by its unique structure; CLIC6 is significantly longer and features a GC-rich segment that encodes a 10 amino acid motif repeated 14 times at the amino-terminus. Additionally, the CLIC6 gene exhibits a rare instance of large-scale segmental paralogy, with a substantial segment on human chromosome 21 being triplicated on chromosomes 1 and 6. CLIC6 is primarily localized in the cytoplasm but translocates to the plasma membrane upon chloride ion efflux, highlighting a dynamic role in cellular signaling. CLIC6 is expressed in various tissues, including the brain, placenta, pancreas, and liver, and interacts with dopamine receptors DRD2, DRD3, and DRD4, further underscoring an importance in neurotransmission and cellular communication. CLIC6 is a 704 amino acid protein with two known isoforms, A and B, and is also referred to as parchorin in rabbit models, making CLIC6 a valuable target for research in cellular physiology and pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLIC6 Antibody (C-3) | sc-515339 | 200 µg/ml | $322.00 | |||
CLIC6 Antibody (C-3): m-IgG3 BP-HRP Bundle | sc-550532 | 200 µg Ab; 40 µg BP | $361.00 | |||
CLIC6 (C-3) Neutralizing Peptide | sc-515339 P | 100 µg/0.5 ml | $69.00 |