CLEC-2 Antibody (53Ex9): sc-73851

CLEC-2 Antibody (53Ex9) is a mouse monoclonal IgG2b antibody that detects CLEC-2 in human samples through western blotting (WB). CLEC-2, also known as C-type lectin domain family 1 member B, is a monomeric, single-pass, type II membrane protein that plays a crucial role in the immune system as a receptor for various ligands, including the snake venom protein rhodocytin. CLEC-2 is predominantly expressed on the surface of platelets and immune cells of myeloid origin, as well as in the liver, highlighting its importance in both hemostasis and immune responses. The activation of CLEC-2 involves the tyrosine phosphorylation of its cytoplasmic tail, which subsequently triggers signaling pathways through phospholipase C gamma 2, leading to platelet activation and aggregation. Moreover, CLEC-2 interacts with podoplanin, a sialoglycoprotein that is implicated in tumor growth regulation and lymphatic vessel formation, underscoring CLEC-2′s multifaceted role in both normal physiology and pathological conditions. With an ability to facilitate critical interactions and signaling events, CLEC-2 is a vital component in the orchestration of immune responses and vascular biology, making anti-CLEC-2 antibody (53Ex9) an essential tool for researchers studying these processes.