cleaved Thrombin APII Antibody (B-7): sc-398087
- cleaved Thrombin APII Antibody (B-7) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 314-329 a short amino acid sequence containing the neoepitope at Arg 323 of Thrombin Activation Peptide 2 of rat origin
- recommended for detection of cleaved Thrombin APII of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for cleaved Thrombin APII Antibody (B-7) for WB applications. This reagent is now offered in a bundle with cleaved Thrombin APII Antibody (B-7) (see ordering information below).
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Cleaved Thrombin APII Antibody (B-7) is a mouse monoclonal IgG3 antibody that detects cleaved Thrombin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cleaved Thrombin, also known as Factor 2, plays a pivotal role in the hemostatic process following tissue injury by being the active form of Prothrombin, which is proteolytically cleaved to generate Thrombin during the coagulation cascade. This serine protease is not only crucial for the formation of fibrin clots but also significantly influences various cellular processes, including mitogenesis, tumor growth, and metastasis. Thrombin′s ability to initiate platelet aggregation and secretion is vital for maintaining vascular integrity during both development and postnatal life. During wound healing, Thrombin coordinates the activity of connective tissue proteins by stimulating fibroblast procollagen production, thereby facilitating tissue repair and regeneration. Anti-cleaved Thrombin antibody (B-7) is an essential tool for researchers studying coagulation processes, vascular biology, and the cellular mechanisms underlying wound healing.
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cleaved Thrombin APII Antibody (B-7) References:
- Multifunctional roles of thrombin. | Narayanan, S. 1999. Ann Clin Lab Sci. 29: 275-80. PMID: 10528826
- Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. | O'Brien, PJ., et al. 2000. J Biol Chem. 275: 13502-9. PMID: 10788464
- Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex. | Maekawa, H., et al. 2000. Thromb Res. 100: 443-51. PMID: 11150588
- Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis. | Hasegawa, M., et al. 2011. J Rheumatol. 38: 129-34. PMID: 21041276
- Structure-function relationships in thrombin-activatable fibrinolysis inhibitor. | Plug, T. and Meijers, JC. 2016. J Thromb Haemost. 14: 633-44. PMID: 26786060
- Thrombin-cellular interactions. | Shuman, MA. 1986. Ann N Y Acad Sci. 485: 228-39. PMID: 3032044
- Thrombin cleaves and activates the protease-activated receptor 2 dependent on thrombomodulin co-receptor availability. | Heuberger, DM., et al. 2019. Thromb Res. 177: 91-101. PMID: 30861432
- Thrombin generation and activity in multiple sclerosis. | Jordan, KR., et al. 2021. Metab Brain Dis. 36: 407-420. PMID: 33411219
- Thrombin cleaves IL-33 and modulates IL-33-activated allergic lung inflammation. | Huang, Y., et al. 2022. Allergy. 77: 2104-2120. PMID: 34995358
- Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin. | Biswas, I., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 603-616. PMID: 38174561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cleaved Thrombin APII Antibody (B-7) | sc-398087 | 200 µg/ml | $322.00 | |||
cleaved Thrombin APII Antibody (B-7): m-IgG3 BP-HRP Bundle | sc-550505 | 200 µg Ab; 40 µg BP | $361.00 | |||
cleaved Thrombin APII (B-7) Neutralizing Peptide | sc-398087 P | 100 µg/0.5 ml | $69.00 |