CLC-2 Antibody (YY9): sc-81871
- CLC-2 Antibody (YY9) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against recombinant CLC-2 of human origin
- recommended for detection of CLC-2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CLC-2 Antibody (YY9). This work is in progress.
CLC-2 Antibody (YY9) is a mouse monoclonal IgG2a antibody that detects CLC-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CLC-2, a member of the voltage-dependent chloride channel family, plays a crucial role in maintaining cellular homeostasis by regulating chloride ion transport across cell membranes. This function is particularly important in epithelial tissues, where CLC-2 is highly expressed, as CLC-2 contributes to fluid secretion and absorption processes, making CLC-2 a potential therapeutic target for conditions like cystic fibrosis. CLC-2′s localization in the epithelial cells of various organs, including the lungs, underscores CLC-2′s significance in respiratory health and disease. CLC-2′s involvement in chloride ion transport not only affects cellular excitability but also influences the overall ionic balance, which is vital for normal physiological functions. Anti-CLC-2 antibody (YY9) enables researchers to gain insights into CLC-2′s role in health and disease, paving the way for potential therapeutic interventions.
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CLC-2 Antibody (YY9) References:
- ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions. | Stölting, G., et al. 2014. Pflugers Arch. 466: 2191-204. PMID: 24638271
- ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. | Jin, Y. and Blikslager, AT. 2015. Tissue Barriers. 3: e1105906. PMID: 26716076
- CLC-2 is a positive modulator of oligodendrocyte precursor cell differentiation and myelination. | Hou, X., et al. 2018. Mol Med Rep. 17: 4515-4523. PMID: 29344669
- ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/β-catenin signaling pathway. | Lu, J., et al. 2018. Cell Mol Biol Lett. 23: 29. PMID: 29988306
- Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies. | Göppner, C., et al. 2021. J Biol Chem. 296: 100074. PMID: 33187987
- Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect. | Fu, SJ., et al. 2021. Int J Mol Sci. 22: PMID: 34070744
- Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina. | Hanke-Gogokhia, C., et al. 2021. FASEB J. 35: e21689. PMID: 34085737
- Electro-steric opening of the CLC-2 chloride channel gate. | De Jesús-Pérez, JJ., et al. 2021. Sci Rep. 11: 13127. PMID: 34162897
- Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. | Ma, T., et al. 2023. Nat Commun. 14: 3424. PMID: 37296152
- NEDD4-2 and the CLC-2 channel regulate neuronal excitability in the pathogenesis of mesial temporal lobe epilepsy. | Liu, Y., et al. 2024. Sci Rep. 14: 4835. PMID: 38418461
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLC-2 Antibody (YY9) | sc-81871 | 50 µg/0.5 ml | $322.00 |