claudin-19 Antibody (B-3): sc-390274

Claudin-19 Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects claudin-19 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Claudin-19 is a crucial member of the claudin family, consisting of 224 amino acids and characterized by its multi-pass membrane structure, which includes four transmembrane domains and two extracellular loops. This unique structure is essential for the formation of tight junctions, which are critical for maintaining the integrity of epithelial and endothelial barriers. Tight junctions regulate paracellular transport, ensuring selective permeability and contributing to the overall homeostasis of tissues. Notably, claudin-19 is expressed in specific regions of various tissues, and expression is tightly regulated, which underscores claudin-19′s importance in physiological processes. Furthermore, mutations in the gene encoding claudin-19 can lead to hypomagnesemia renal with ocular involvement (HOMGO), a serious condition that highlights claudin-19′s role in renal function and magnesium homeostasis. Anti-claudin-19 antibody (B-3) is an invaluable tool for researchers investigating the molecular mechanisms underlying tight junction integrity and related pathologies.

The preferred claudin-19 antibody is claudin-19 Antibody (C-5): sc-365967.