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clasto-Lactacystin β-lactone, a synthetic derivative of lactahydrin, is a cell permeable, irreversible and specific inhibitor of the 20S proteasome involved in the ubiquitin-proteasome degradation pathway. Kinetic studies indicate that clasto-Lactacystin β-lactone interacts with the proteasome at its catalytic site threonines, which opens the β-lactone ring and allows the proteasome's catalytic hydroxyl group to become acylated. clasto-Lactacystin β-lactone has been reported to rapidly enter cells in mammalian cell culture media and to additionally inactivate the proteasome in Jurkat cells in a dose-dependent manner. In addition, clasto-Lactacystin β-lactone is reported to inhibit cathepsin A, lead to adipogenesis and induce neurite growth in rat PC12 cells.
1. Fenteany, G., et al. 1995. Science. 268: 726-731. PMID: 7732382
2. Dick, L.R., et al. 1997. J. Biol. Chem. 272: 182-188. PMID: 8995245
3. Obin, M., et al. 1999. J. Biol. Chem. 274: 11789-11795. PMID: 10206996
4. Kisselev, A.F., et al. 2001. Chem. Biol. 8: 739-758. PMID: 11514224
See how others have used clasto-Lactacystin beta-lactone. Click on the entry to view the PubMed entry .
PMID: # 28261569 Rucks, EA. et al. 2017. Frontiers in cellular and infection microbiology. 7: 40.
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