Molecular structure of Cl-HIBO, CAS Number: 909400-43-7
Cl-HIBO (CAS 909400-43-7)
Alternate Names:
Chloro-homoibotenic acid
Application:
Cl-HIBO is Chloro-homoibotenic acid, a highly desensitising AMPA receptor agonist. Subtype selective for GluR1 and GluR2 subunit-containing receptors
CAS Number:
909400-43-7
Molecular Weight:
206.58
Molecular Formula:
C6H7ClN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Cl-HIBO is a hghly desensitising AMPA receptor agonist. Subtype selective for GluR1 and GluR2 subunit-containing receptors. Cl-HIBO is an activator of GluR-1 and GluR-2.
Cl-HIBO (CAS 909400-43-7) References
- Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). | Bjerrum, EJ., et al. 2003. J Med Chem. 46: 2246-9. PMID: 12747796
- 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists. | Greenwood, JR., et al. 2006. Neuropharmacology. 51: 52-9. PMID: 16631211
- A tetrazolyl-substituted subtype-selective AMPA receptor agonist. | Vogensen, SB., et al. 2007. J Med Chem. 50: 2408-14. PMID: 17455929
- Structure of the S1S2 glutamate binding domain of GLuR3. | Ahmed, AH., et al. 2009. Proteins. 75: 628-37. PMID: 19003990
- Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. | Frydenvang, K., et al. 2010. J Med Chem. 53: 8354-61. PMID: 21067182
- A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure. | Szymańska, E., et al. 2011. J Med Chem. 54: 7289-98. PMID: 21923187
- Ligand-Directed Chemistry of AMPA Receptors Confers Live-Cell Fluorescent Biosensors. | Kiyonaka, S., et al. 2018. ACS Chem Biol. 13: 1880-1889. PMID: 29437380
- Inhibition of AMPA (α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate) Receptor Reduces Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice. | Kawakita, F., et al. 2022. Transl Stroke Res. 13: 326-337. PMID: 34342874
- Anti-Apoptotic Effects of AMPA Receptor Antagonist Perampanel in Early Brain Injury After Subarachnoid Hemorrhage in Mice. | Kawakita, F., et al. 2023. Transl Stroke Res.. PMID: 36757633
Activator of:
GluR-1, and GluR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cl-HIBO, 10 mg | sc-205934 | 10 mg | $229.00 | |||
| US: Only available in the US | ||||||
Cl-HIBO, 50 mg | sc-205934A | 50 mg | $970.00 | |||
| US: Only available in the US | ||||||