Molecular structure of CL-387,785, CAS Number: 194423-06-8
CL-387,785 (CAS 194423-06-8)
See product citations (1)
Alternate Names:
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; EKI-785
Application:
CL-387,785 is an irreversible inhibitor of EGF-receptor kinase activity
CAS Number:
194423-06-8
Molecular Weight:
381.2
Molecular Formula:
C18H13BrN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CL-387,785 irreversibly inhibits EGF-receptor (EGFR) kinase activity as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR. CL-387,785 also blocks EGF-mediated growth in A431 cells. The compound inhibits proliferation of EGFR or c-ErbB2 expressing cells by covalently binding to the EGFR.
CL-387,785 (CAS 194423-06-8) References
Sweeney, W.E., et al. 2000. Kidney Int. 57, 33. Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917. Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.Inhibitor of:
EGFR.Activator of:
SHKBP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CL-387,785, 1 mg | sc-221429 | 1 mg | $134.00 |