Molecular structure of CL 218872, CAS Number: 66548-69-4
CL 218872 (CAS 66548-69-4)
Application:
CL 218872 is a benzodiazepine agonist selective for α1 subunit-containing GABAA receptors
CAS Number:
66548-69-4
Purity:
>99%
Molecular Weight:
278.24
Molecular Formula:
C13H9F3N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively).
CL 218872 (CAS 66548-69-4) References
- Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA-receptor function. | Galpern, WR., et al. 1990. Br J Pharmacol. 101: 839-42. PMID: 1964820
- Modulation of the electrically evoked release of 5-[3H]hydroxytryptamine from rat cerebral cortex: effects of alpidem, CL 218872, and diazepam. | Lista, A., et al. 1988. J Neurochem. 51: 1414-21. PMID: 2844992
- Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice. Comparison with triazolam and CL 218,872. | Sanger, DJ., et al. 1986. Psychopharmacology (Berl). 90: 207-10. PMID: 2878460
- Comparison of the effects of chlordiazepoxide and CL 218,872 on serum corticosterone concentrations in rats. | McElroy, JF., et al. 1987. Psychopharmacology (Berl). 91: 467-72. PMID: 2884689
- Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits. | Longo, VG., et al. 1988. Pharmacol Biochem Behav. 29: 785-90. PMID: 2901117
- Binding characteristics of 3H-flunitrazepam and CL-218,872 in cerebellum and cortex of C57B1 mice made tolerant to and dependent on phenobarbital or ethanol. | Liljequist, S. and Tabakoff, B. 1985. Alcohol. 2: 215-20. PMID: 2990504
- Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. | Squires, RF., et al. 1979. Pharmacol Biochem Behav. 10: 825-30. PMID: 40257
- Benzodiazepine receptors: cellular and behavioral characteristics. | Lippa, AS., et al. 1979. Pharmacol Biochem Behav. 10: 831-43. PMID: 40258
- Benzodiazepine receptor ligand actions on GABA responses. Benzodiazepines, CL 218872, zopiclone. | Skerritt, JH. and Macdonald, RL. 1984. Eur J Pharmacol. 101: 127-34. PMID: 6086357
- CL 218,872 binding to benzodiazepine receptors in rat spinal cord: modulation by gamma-aminobutyric acid and evidence for receptor heterogeneity. | Villiger, JW. 1984. J Neurochem. 43: 903-5. PMID: 6088698
- Benzodiazepine receptor binding in young, mature and senescent rat brain and kidney. | Pedigo, NW., et al. 1981. Neurobiol Aging. 2: 83-8. PMID: 6272144
- gamma-Aminobutyric acid enhancement of CL 218,872 affinity and evidence of benzodiazepine receptor heterogeneity. | Regan, JW., et al. 1981. Mol Pharmacol. 20: 477-83. PMID: 6276709
- Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | Sieghart, W. 1995. Pharmacol Rev. 47: 181-234. PMID: 7568326
Activator of:
GABAA R α 1, GABAA R α 2, GABAA R α 3, and GABAA R α 5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CL 218872, 10 mg | sc-203552 | 10 mg | $85.00 | |||
CL 218872, 50 mg | sc-203552A | 50 mg | $319.00 |