CKR-7 Antibody (ELC-Fc): sc-23936

CKR-7 Antibody (ELC-Fc) is a human IgG1 Fc chimera antibody that detects CKR-7 protein of mouse, rat, and human origin by immunofluorescence (IF) and flow cytometry (FCM). CKR-7 Antibody (ELC-Fc) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CKR-7, also known as C-C chemokine receptor type 7, CCR7, CMKBR7, EBI1, or EVI1, is a 378 amino acid multi-pass membrane protein that plays a crucial role in the immune system by mediating the migration of lymphocytes to sites of inflammation. This receptor is primarily expressed in activated B- and T-lymphocytes, as well as in various lymphoid tissues, and functions as a receptor for the chemokine MIP-3β. CKR-7 facilitates normal lymphocyte function, which is essential for an effective immune response. Additionally, CKR-7 is part of the C-C chemokine receptor family, which includes several other receptors that are G protein-coupled and integral to the chemotaxis of immune cells. Understanding CKR-7 function is vital, as dysregulation can contribute to various pathological conditions, including autoimmune diseases and cancer, where altered lymphocyte trafficking can lead to inappropriate immune responses.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CKR-7 Antibody (ELC-Fc) References:

1. CCR7 as a therapeutic target in Cancer.  |  Salem, A., et al. 2021. Biochim Biophys Acta Rev Cancer. 1875: 188499. PMID: 33385485
2. CCR7 in Blood Cancers - Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target.  |  Cuesta-Mateos, C., et al. 2021. Front Oncol. 11: 736758. PMID: 34778050
3. New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases.  |  Hong, W., et al. 2022. Front Pharmacol. 13: 841687. PMID: 35281921
4. CCL21/CCR7 axis as a therapeutic target for autoimmune diseases.  |  Han, L. and Zhang, L. 2023. Int Immunopharmacol. 121: 110431. PMID: 37331295
5. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.  |  Schweickart, VL., et al. 1994. Genomics. 23: 643-50. PMID: 7851893
6. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.  |  Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
7. Identification of a major co-receptor for primary isolates of HIV-1.  |  Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
8. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.  |  Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
9. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.  |  Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
10. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  |  Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
11. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.  |  Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
12. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.  |  Baba, M., et al. 1997. J Biol Chem. 272: 14893-8. PMID: 9169459

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CKR-7 Antibody (ELC-Fc) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CKR-7 Antibody (ELC-Fc) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CKR-7 Antibody (ELC-Fc) Specifications

Alternate Product Name: CCR7

Product Clone Name: ELC-Fc

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CKR-7

Epitope Species: human

Product Reactivity/Detection: CKR-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CKR-7 Antibody (ELC-Fc): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin