CKR-7 Antibody (617CT2.2.1): sc-517322

CKR-7 Antibody (617CT2.2.1) is a mouse monoclonal IgG1 antibody that detects CKR-7 of human origin by western blotting (WB). Anti-CKR-7 antibody (617CT2.2.1) is available in a non-conjugated form, specifically designed for researchers seeking to study the C-C chemokine receptor type 7, also known as CCR7, CMKBR7, EBI1, or EVI1. This 378 amino acid multi-pass membrane protein is predominantly expressed in activated B- and T-lymphocytes, as well as in various lymphoid tissues, playing a crucial role in the immune response. CKR-7 functions as a receptor for the chemokine MIP-3β, which is essential for mediating normal lymphocyte function and guiding the migration of immune cells to sites of inflammation. Proper functioning of CKR-7 is vital for maintaining immune homeostasis and facilitating adaptive immune response, as CKR-7 helps orchestrate lymphocyte movement within the body. CKR-7 is implicated in various pathological conditions, including viral infections, where CKR-7 may facilitate virus entry into host cells. Understanding CKR-7 dynamics and interactions can provide valuable insights into immune system regulation and potential therapeutic targets for diseases involving immune dysregulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CKR-7 Antibody (617CT2.2.1) References:

1. Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation.  |  Noor, S. and Wilson, EH. 2012. J Neuroinflammation. 9: 77. PMID: 22533989
2. Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway.  |  Zhong, G., et al. 2017. Mol Med Rep. 15: 4100-4108. PMID: 28487957
3. Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.  |  Mueller, PA., et al. 2018. Circulation. 138: 1850-1863. PMID: 29794082
4. Locally Trapping the C-C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection.  |  An, S., et al. 2019. Small. 15: e1805182. PMID: 30690891
5. Curcumae Radix Extract Decreases Mammary Tumor-Derived Lung Metastasis via Suppression of C-C Chemokine Receptor Type 7 Expression.  |  Kaya, P., et al. 2019. Nutrients. 11: PMID: 30781353
6. Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors.  |  Zu, G., et al. 2019. Cancer Manag Res. 11: 1881-1892. PMID: 30881115
7. Exacerbation of non-steroidal anti-inflammatory drug-induced enteropathy in C-C chemokine receptor type 7-deficient mice.  |  Yamaguchi, T., et al. 2022. J Gastroenterol Hepatol. 37: 1561-1570. PMID: 35435994
8. Effects of let-7a microRNA and C-C chemokine receptor type 7 expression on cellular function and prognosis in esophageal squamous cell carcinoma.  |  Yura, M., et al. 2022. BMC Cancer. 22: 1064. PMID: 36243683
9. The role of the 47-kDa membrane lipoprotein of Treponema pallidum in promoting maturation of peripheral blood monocyte-derived dendritic cells without enhancing C-C chemokine receptor type 7-mediated dendritic cell migration.  |  Cheng, W., et al. 2023. Adv Clin Exp Med. 32: 369-377. PMID: 36330841
10. C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell homeostasis and response to acute liver injury.  |  Niemietz, P., et al. 2024. Hepatology. 80: 1104-1119. PMID: 38231043

The preferred CKR-7 antibody is CKR-7 Antibody (ELC-Fc): sc-23936.