CJ-21058 (CAS 405072-57-3)
CAS Number:
405072-57-3
Molecular Weight:
387.5
Molecular Formula:
C23H33NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CJ-21058 can be derived from equisetin. It exhibits antibacterial activity against Gram-positive bacteria. This activity is due to its inhibition of ATP-dependent translocation of precursor proteins across the bacterial cell membrane, targeting the SecA component of the bacterial translocation machinery. CJ-21058 shows SecA inhibitory activity with an IC50 of 15μg/ml and demonstrates good growth inhibitory activity against specific bacteria strains with a minimum inhibitory concentration (MIC) of 5μg/ml, alongside moderate cytotoxicity against HeLa cells with an IC90 of 32μg/ml.
CJ-21058 (CAS 405072-57-3) References
- Discovery of the first SecA inhibitors using structure-based virtual screening. | Li, M., et al. 2008. Biochem Biophys Res Commun. 368: 839-45. PMID: 18261984
- Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. | Patham, B., et al. 2009. Biochem J. 419: 507-17. PMID: 19196237
- Drug screening by crossing membranes: a novel approach to identification of trypanocides. | Field, MC. 2009. Biochem J. 419: e1-3. PMID: 19309311
- Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors. | Jang, MY., et al. 2011. Bioorg Med Chem. 19: 702-14. PMID: 21094610
- Traffic jam at the bacterial sec translocase: targeting the SecA nanomotor by small-molecule inhibitors. | Segers, K. and Anné, J. 2011. Chem Biol. 18: 685-98. PMID: 21700205
- Screening strategies for discovery of antibacterial natural products. | Singh, SB., et al. 2011. Expert Rev Anti Infect Ther. 9: 589-613. PMID: 21819327
- Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation. | Huang, YJ., et al. 2012. ChemMedChem. 7: 571-7. PMID: 22354575
- Epi-trichosetin, a new undecaprenyl pyrophosphate synthase inhibitor, produced by Fusarium oxysporum FKI-4553. | Inokoshi, J., et al. 2013. J Antibiot (Tokyo). 66: 549-54. PMID: 23715038
- Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents. | Van Puyenbroeck, V. and Vermeire, K. 2018. Cell Mol Life Sci. 75: 1541-1558. PMID: 29305616
- Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen. | Hamed, MB., et al. 2021. Microorganisms. 9: PMID: 33805695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CJ-21058, 1 mg | sc-280646 | 1 mg | $215.00 | |||
CJ-21058, 5 mg | sc-280646A | 5 mg | $805.00 |