Molecular structure of CJ 033466, CAS Number: 519148-48-2
CJ 033466 (CAS 519148-48-2)
Application:
CJ 033466 is a partial, potent, and selective SR-4 agonist
CAS Number:
519148-48-2
Molecular Weight:
377.91
Molecular Formula:
C19H28ClN5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
5-HT4 partial agonist that is potent and selective. Selectivity for 5-HT4 is substantially greater than that of 5-HT and D2 receptors. Upon oral administration, displays gastro-prokinetic effects. Blocking of hERG is weak.
CJ 033466 (CAS 519148-48-2) References
- The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. | Toga, T., et al. 2007. J Pharmacol Sci. 105: 207-10. PMID: 17928736
- In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor. | Mikami, T., et al. 2009. Eur J Pharmacol. 609: 5-12. PMID: 19285067
- Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system. | Filip, M. and Bader, M. 2009. Pharmacol Rep. 61: 761-77. PMID: 19903999
- Serotonin 5-HT3 and 5-HT4 ligands: an update of medicinal chemistry research in the last few years. | Modica, MN., et al. 2010. Curr Med Chem. 17: 334-62. PMID: 20015043
- Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus. | Tsuchida, Y., et al. 2011. Gut. 60: 638-47. PMID: 21115544
- 5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. | Boakye, PA., et al. 2012. Neurogastroenterol Motil. 24: e27-40. PMID: 22074563
- New therapeutic strategies for postoperative ileus. | van Bree, SH., et al. 2012. Nat Rev Gastroenterol Hepatol. 9: 675-83. PMID: 22801725
- The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut. | Takaki, M., et al. 2014. J Neurogastroenterol Motil. 20: 17-30. PMID: 24466442
- Cholinergic immunomodulation in inflammatory bowel diseases. | Serafini, MA., et al. 2022. Brain Behav Immun Health. 19: 100401. PMID: 34977822
Activator of:
Serotonin, and SR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CJ 033466, 10 mg | sc-205257 | 10 mg | $135.00 | |||
| US: Only available in the US | ||||||
CJ 033466, 50 mg | sc-205257A | 50 mg | $575.00 | |||
| US: Only available in the US | ||||||