citrin Antibody (8Z): sc-100937

Citrin Antibody (8Z) is a mouse monoclonal IgG2a antibody that detects citrin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass membrane protein predominantly located in the inner membrane of the mitochondrion, where citrin plays a crucial role in cellular metabolism. As a calcium-dependent carrier for glutamate and aspartate, citrin is integral to the urea cycle, facilitating the transport of these amino acids across mitochondrial membranes, which is essential for nitrogen metabolism and detoxification processes in the liver. Defects in the gene encoding citrin lead to serious metabolic disorders, including citrullinemia type 2 and neonatal intrahepatic cholestasis due to citrin deficiency, both of which can result in significant neuropsychiatric symptoms and developmental issues. The presence of citrin in various tissues, including the liver, pancreas, kidney, brain, heart, and placenta, underscores citrin′s importance in maintaining metabolic homeostasis and highlights the potential impact of citrin dysfunction on overall health. Anti-citrin antibody (8Z) is an invaluable tool for researchers studying these critical pathways and the associated diseases.

The preferred citrin antibody is citrin Antibody (D-7): sc-393303.