Molecular structure of Citilistat, CAS Number: 282526-98-1
Citilistat (CAS 282526-98-1)
Alternate Names:
Cetilistat
Application:
Citilistat is a novel lipase inhibitor
CAS Number:
282526-98-1
Molecular Weight:
401.58
Molecular Formula:
C25H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Citilistat is primarily studied for its applications in the field of enzyme inhibition, particularly focusing on its interactions with pancreatic lipases. This research is important in understanding how Citilistat alters the activity of these enzymes, which play a role in the breakdown and absorption of dietary fats. Studies involve exploring the molecular binding mechanisms of Citilistat, which help in designing more effective enzyme inhibitors. The impact of Citilistat on the rate of lipase activity and its specificity towards different substrates are also critical areas of investigation, providing insights into its potential utility in various industrial processes. Additionally, the stability of Citilistat under different environmental conditions and its effects on the kinetics of enzyme inhibition are rigorously analyzed to enhance its application in biochemical research.
Citilistat (CAS 282526-98-1) References
- Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. | Yamada, Y., et al. 2008. Horm Metab Res. 40: 539-43. PMID: 18500680
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation. | Durgampudi, C., et al. 2014. Am J Pathol. 184: 1773-84. PMID: 24854864
- A general analytical platform and strategy in search for illegal drugs. | Johansson, M., et al. 2014. J Pharm Biomed Anal. 100: 215-229. PMID: 25171485
- Computational analysis and enzyme assay of inhibitor response to disease single nucleotide polymorphisms (SNPs) in lipoprotein lipase. | He, D., et al. 2016. J Bioinform Comput Biol. 14: 1650028. PMID: 27427383
- Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas. | Lin, YP., et al. 2018. PLoS One. 13: e0205371. PMID: 30304050
- Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants. | Elbashir, SMI., et al. 2018. BMC Complement Altern Med. 18: 282. PMID: 30340582
- Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities. | Dirar, AI., et al. 2019. Medicines (Basel). 6: PMID: 31766752
- Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods. | Ruangaram, W. and Kato, E. 2020. Pharmaceuticals (Basel). 13: PMID: 32235329
- In vivo metabolic investigation of cetilistat in normal versus pseudo-germ-free rats using UPLC-QTOFMS/MS and in silico toxicological evaluation of its metabolites. | Tiwari, SS., et al. 2020. Biomed Chromatogr. 34: e4860. PMID: 32311767
- Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system. | Yuan, S., et al. 2020. Pharmacol Res. 159: 104960. PMID: 32473310
- Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches. | Watashi, K. 2021. Biochem Biophys Res Commun. 538: 137-144. PMID: 33272566
- Chemical Constituents of the Bulbs of Scilla peruviana and Their Pancreatic Lipase Inhibitory Activity. | Matsuo, Y., et al. 2021. Int J Mol Sci. 22: PMID: 33514028
- Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approach. | Shahabadi, N., et al. 2021. Inform Med Unlocked. 26: 100745. PMID: 34568544
- Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and remdesivir as potential inhibitors against RNA dependent RNA polymerase of SARS-CoV-2: A comparative in silico perspective. | Shahabadi, N., et al. 2023. Inform Med Unlocked. 36: 101147. PMID: 36510496
- Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI2 and D2O. | Li, H., et al. 2023. Molecules. 28: PMID: 36615608
Inhibitor of:
1700016H13Rik, ACOT8, colipase, EG329055, Gastric Lipase, Gm1679, LIPH, LIPN, LIPT2, LPAAT-ε, LPL, MULK, NDUFB11, PLRP3, and PTPLB.Activator of:
stefin A1, and stefin A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Citilistat, 250 mg | sc-358100 | 250 mg | $46.00 | |||
Citilistat, 1 g | sc-358100A | 1 g | $102.00 |