Citicoline sodium salt (CAS 33818-15-4)
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Citicoline sodium salt is a nontoxic intermediate in the biological synthesis of phosphotidylcholine from choline. Studies indicate that Citicoline sodium salt can increase dopamine receptor densities. In addition, Citicoline sodium salt induces the increases Adrenocorticotropic hormone (ACTH) levels in a Corticotropin-releasing hormone (CRH) independent manner. Other hormones of the hypothalamic–pituitary–adrenal axis are also increased such as LH, FSH, GH and TSH. Studies conducted on brain cells show that Citicoline sodium salt can reverse the toxic effects caused by hypoxia, ischemia, and trauma. It is suggested that these neuroprotective properties of Citicoline sodium salt may involve reinforcement of intracellular glutathione antioxidative system, attenuation of phospholipase A, activation and prevention of phospholipid degradation, and prevention of glutamate neurotoxicity. We also offer Citicoline as Cytidine 5′-diphosphocholine, Sodium Salt (CDP-choline), sc-278862.
Citicoline sodium salt (CAS 33818-15-4) References
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- Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat. | Schuettauf, F., et al. 2006. Exp Eye Res. 83: 1128-34. PMID: 16876158
- Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats. | Özay, R., et al. 2007. Surg Neurol. 68: 615-622. PMID: 18053855
- CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. | Fiedorowicz, M., et al. 2008. Acta Neurobiol Exp (Wars). 68: 389-97. PMID: 18668162
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- Development and Validation of Reverse-phase High-performance Liquid Chromatography Method for Estimation of Citicoline Sodium in Bulk and Dosage Form. | Maradiya, HK. and Pansara, VH. 2013. Indian J Pharm Sci. 75: 238-41. PMID: 24019577
- Beneficial effects of exogenous CDP-choline (citicoline) in EAE. | Grieb, P. 2015. Brain. 138: e388. PMID: 26001722
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- Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. | Wang, NQ., et al. 2015. Evid Based Complement Alternat Med. 2015: 369021. PMID: 26697095
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution. | Carnevale, C., et al. 2019. PLoS One. 14: e0224982. PMID: 31725734
- Spectrofluorimetric approach for determination of citicoline in the presence of co-formulated piracetam through fluorescence quenching of eosin Y. | Omar, MA., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 236: 118337. PMID: 32320917
- Citicoline Treatment in Acute Ischemic Stroke: A Randomized, Single-Blind TMS Study. | Premi, E., et al. 2022. Front Neurol. 13: 915362. PMID: 35923827
- Brain Targeting of Citicoline Sodium via Hyaluronic Acid-Decorated Novel Nano-Transbilosomes for Mitigation of Alzheimer's Disease in a Rat Model: Formulation, Optimization, in vitro and in vivo Assessment. | AbouElhassan, KM., et al. 2022. Int J Nanomedicine. 17: 6347-6376. PMID: 36540376
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Citicoline sodium salt, 100 mg | sc-300380 | 100 mg | $76.00 | |||
Citicoline sodium salt, 1 g | sc-300380A | 1 g | $487.00 |